Medicine Information

Furotil

Name: Furotil
Brand: Furotil

Injection750 mgAntibiotics, CephalosporinsATC: J01DC02

Generic Name

Cefuroxime

Manufacturer

Square Pharmaceuticals PLC

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
furotil 750 mg injection	৳ 175.00	N/A

Description

Overview of the medicine

Cefuroxime is a second-generation cephalosporin antibiotic used to treat a wide range of bacterial infections. It works by stopping the growth of bacteria.

Uses & Indications

Respiratory tract infections (e.g., bronchitis, pneumonia)

Urinary tract infections (e.g., pyelonephritis, cystitis)

Skin and soft tissue infections (e.g., cellulitis, erysipelas)

Bone and joint infections

Septicaemia

Meningitis

Prophylaxis against infection in abdominal, pelvic, and orthopedic surgery

Dosage

Adults

750 mg every 8 hours by IM or IV injection. In more severe infections, dosage may be increased to 1.5 g every 8 hours. Max 3-6 g/day.

Elderly

Similar to adults, but dosage adjustment may be necessary in case of renal impairment.

Renal_impairment

Dosage adjustment is required based on creatinine clearance. For CrCl 10-20 mL/min: 750 mg once daily. For CrCl <10 mL/min: 750 mg every 24-48 hours.

How to Take

Furotil 750 mg Injection is administered by deep intramuscular (IM) injection or by slow intravenous (IV) injection over 3 to 5 minutes, or by continuous IV infusion. For IM use, reconstitute with sterile water for injection.

Mechanism of Action

Cefuroxime is a bactericidal agent that acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs), which interferes with the final transpeptidation step of peptidoglycan synthesis in the bacterial cell wall, thereby inhibiting cell wall biosynthesis and leading to cell lysis.

Pharmacokinetics

Onset

Rapid, typically within minutes for intravenous (IV) administration.

Excretion

Excreted unchanged in the urine, primarily via glomerular filtration and tubular secretion. Approximately 50% of the dose is excreted within 2 hours.

Half life

Approximately 1 to 1.5 hours in adults with normal renal function.

Absorption

Rapidly absorbed after intramuscular (IM) injection. Peak plasma concentrations are achieved within 30-60 minutes.

Metabolism

Cefuroxime is not metabolized significantly in the body.

Side Effects

Contraindications

Hypersensitivity to cefuroxime, any other cephalosporin antibiotic, or any of the excipients.
History of severe hypersensitivity (e.g., anaphylactic reaction) to any other type of beta-lactam antibacterial agent (e.g., penicillins, monobactams, carbapenems).

Drug Interactions

Probenecid

Concomitant administration with probenecid increases the area under the serum concentration versus time curve (AUC) of cefuroxime by approximately 50%, prolonging its half-life.

Aminoglycosides

Concurrent use of high doses of cephalosporins with aminoglycosides or potent diuretics may increase the risk of nephrotoxicity.

Oral anticoagulants

Cephalosporins, including cefuroxime, may rarely cause prolonged prothrombin time. Caution is advised when cefuroxime is administered concomitantly with oral anticoagulants.

Storage

Store below 25°C to 30°C, protected from light and moisture. Reconstituted solution should be used immediately or stored for a limited time (e.g., 24 hours at 2-8°C or 5 hours at 25°C) depending on specific product instructions.

Overdose

Symptoms of overdose may include cerebral irritation leading to convulsions. Management is primarily supportive and symptomatic. Hemodialysis may be useful in reducing cefuroxime serum levels.

Pregnancy & Lactation

Pregnancy Category B. Cefuroxime crosses the placenta and is excreted in breast milk. While generally considered safe, it should be used with caution during pregnancy and lactation only if clearly needed and under medical supervision.

Side Effects

Contraindications

Hypersensitivity to cefuroxime, any other cephalosporin antibiotic, or any of the excipients.
History of severe hypersensitivity (e.g., anaphylactic reaction) to any other type of beta-lactam antibacterial agent (e.g., penicillins, monobactams, carbapenems).

Drug Interactions

Probenecid

Concomitant administration with probenecid increases the area under the serum concentration versus time curve (AUC) of cefuroxime by approximately 50%, prolonging its half-life.

Aminoglycosides

Concurrent use of high doses of cephalosporins with aminoglycosides or potent diuretics may increase the risk of nephrotoxicity.

Oral anticoagulants

Cephalosporins, including cefuroxime, may rarely cause prolonged prothrombin time. Caution is advised when cefuroxime is administered concomitantly with oral anticoagulants.

Storage

Overdose

Symptoms of overdose may include cerebral irritation leading to convulsions. Management is primarily supportive and symptomatic. Hemodialysis may be useful in reducing cefuroxime serum levels.

Pregnancy & Lactation

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

Single vial with solventBox of 5 vials with solvent

Shelf Life

Typically 2 to 3 years from the manufacturing date, when stored as per recommendations.

Availability

Pharmacies, Hospitals

Approval Status

Approved

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Cefuroxime has undergone extensive clinical trials since its introduction, demonstrating efficacy in a wide range of bacterial infections. Ongoing research focuses on its role in antibiotic resistance patterns and new indications.

Lab Monitoring

Renal function tests (e.g., creatinine, BUN), especially in patients with pre-existing renal impairment or those receiving high doses.
Liver function tests (e.g., AST, ALT) in case of prolonged therapy or suspected hepatic dysfunction.
Complete Blood Count (CBC) with differential for prolonged treatment periods.

Doctor Notes

Monitor patients for signs of superinfection, especially with prolonged use.
Adjust dosage in patients with renal impairment.
Be aware of potential cross-reactivity in patients with a history of penicillin allergy, though rare with cephalosporins.

Patient Guidelines

Complete the full prescribed course of antibiotics, even if symptoms improve, to prevent the development of antibiotic resistance.
Report any severe or persistent side effects to your doctor immediately.
Do not share this medicine with others, even if they have similar symptoms.

Missed Dose Advice

If a dose is missed, it should be administered as soon as remembered, unless it is almost time for the next scheduled dose. In that case, skip the missed dose and resume the regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Furotil 750 mg Injection may cause dizziness in some patients. Patients should be advised to exercise caution when driving or operating machinery until they know how the medicine affects them.