g-hyoscine
Generic Name
Hyoscine Butylbromide 20 mg Injection
Manufacturer
Global Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| g hyoscine 20 mg injection | ৳ 10.00 | N/A |
Description
Overview of the medicine
Hyoscine Butylbromide is an antispasmodic agent used to relieve cramps in the gastrointestinal tract, genitourinary tract, and biliary tract. It works by relaxing smooth muscles and is typically administered by injection for rapid effect.
Uses & Indications
Dosage
Adults
20 mg intramuscularly (IM) or intravenously (IV), slowly. May be repeated after 30 minutes if needed, up to a maximum of 100 mg in 24 hours.
Elderly
Same as adults, but caution advised due to potential for increased sensitivity to anticholinergic effects.
Renal_impairment
No specific dose adjustment generally needed, but use with caution. Monitor for adverse effects.
How to Take
Administer slowly by intravenous injection (over 1 minute) or intramuscularly into a large muscle. Must be administered by a healthcare professional.
Mechanism of Action
Hyoscine Butylbromide acts by blocking the muscarinic acetylcholine receptors, thereby exerting a spasmolytic effect on the smooth muscles of the gastrointestinal, biliary, and genitourinary tracts. It has little to no central nervous system effects due to its quaternary ammonium structure.
Pharmacokinetics
Onset
Within minutes (IV), 15-30 minutes (IM).
Excretion
Mainly renal (unchanged drug and metabolites), some biliary/fecal.
Half life
Approximately 4.5-8 hours.
Absorption
Poor oral absorption, very low bioavailability. After IM/IV administration, systemic absorption is rapid and complete.
Metabolism
Primarily hydrolyzed in the liver and partially excreted unchanged.
Side Effects
Contraindications
- •Hypersensitivity to hyoscine butylbromide or any component
- •Myasthenia gravis
- •Megacolon
- •Narrow-angle glaucoma
- •Prostatic hypertrophy with urinary retention
- •Mechanical stenosis in the gastrointestinal tract
- •Paralytic or obstructive ileus
- •Tachycardia
Drug Interactions
Quinidine
Enhanced anticholinergic effects.
Amantadine
Enhanced anticholinergic effects.
Antihistamines
Enhanced anticholinergic effects.
Beta-adrenergic agents
Increased heart rate.
Tricyclic antidepressants
Enhanced anticholinergic effects.
Dopamine antagonists (e.g., metoclopramide)
Reduced effects of both drugs on gastrointestinal motility.
Storage
Store below 25°C, protect from light. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose include anticholinergic effects like dry mouth, blurred vision, tachycardia, urinary retention, skin flushing, and hyperthermia. Treatment is symptomatic and supportive. Physostigmine may be considered in severe cases as an antidote.
Pregnancy & Lactation
Limited data available. Use with caution during pregnancy and lactation, only if clearly needed and benefits outweigh potential risks. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years from the date of manufacture, depending on the manufacturer.
Availability
Hospitals, retail pharmacies
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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