For external use only. Cleanse and debride the burn wound before applying a thin layer of cream to the affected area. The cream should be applied with a sterile gloved hand. The wound should be covered with the cream at all times. Redressing may be required daily or more frequently depending on the amount of exudate.

The exact mechanism of action is not fully elucidated, but it is believed that silver sulfadiazine acts on the bacterial cell wall and membrane to produce a bactericidal effect. The silver ions disrupt the DNA structure and function, while the sulfadiazine component interferes with bacterial folate synthesis, thereby inhibiting bacterial growth.

• •Hypersensitivity to silver sulfadiazine or any component of the formulation, or to sulfonamides.
• •Premature infants or neonates (risk of kernicterus).
• •Full-term pregnant women near delivery (risk of kernicterus in the newborn).
• •Patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency (risk of hemolytic anemia).

Store at controlled room temperature (15-30°C / 59-86°F). Protect from light and freezing. Keep out of reach of children.

Accidental ingestion or extensive topical application on large areas could lead to systemic absorption and signs of sulfonamide toxicity (e.g., nausea, vomiting, crystalluria, hematological disorders). Treatment is supportive and symptomatic, including maintaining adequate hydration to prevent crystalluria.

Pregnancy Category B. However, avoid in full-term pregnant women near delivery due to the risk of kernicterus in the newborn. Lactation: Not recommended for nursing mothers of premature infants or those with G6PD deficiency, due to the risk of sulfonamide exposure.