Gavista
Generic Name
Gabapentin (250 mg chewable tablet)
Manufacturer
Drug International Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| gavista 250 mg chewable tablet | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Gavista (Gabapentin) is an anticonvulsant and neuropathic pain medication. It is used to treat partial seizures in adults and children (3 years and older) and postherpetic neuralgia (nerve pain after shingles) in adults. The chewable form facilitates administration.
Uses & Indications
Dosage
Adults
Dosage is individualized and titrated. For neuropathic pain: initial 300 mg once daily on Day 1, then 300 mg twice daily on Day 2, then 300 mg three times daily on Day 3. May increase to 900-1800 mg/day (in 3 divided doses). For seizures: initial 300 mg three times daily, may increase to 900-3600 mg/day (in 3 divided doses). Gavista 250 mg chewable tablet should be chewed thoroughly before swallowing.
Elderly
Dosage should be adjusted based on renal function due to age-related decline in kidney function.
Renal_impairment
Dosage must be reduced in patients with impaired renal function (creatinine clearance < 60 mL/min). Specific dose adjustments depend on the degree of impairment and should be determined by a physician.
How to Take
Gavista chewable tablets are for oral administration. They should be chewed thoroughly before swallowing. Can be taken with or without food. Ensure regular dosing times to maintain consistent blood levels.
Mechanism of Action
The exact mechanism of gabapentin is not fully understood, but it is believed to modulate the release of excitatory neurotransmitters by binding to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. It does not bind to GABA-A or GABA-B receptors or affect GABA uptake or degradation.
Pharmacokinetics
Onset
Varies by indication; anticonvulsant effects may take days to optimize. Pain relief onset can be within hours for acute doses, but full therapeutic effect requires titration.
Excretion
Exclusively excreted by the kidneys as unchanged drug. Renal clearance is directly proportional to creatinine clearance.
Half life
Approximately 5 to 7 hours in adults with normal renal function.
Absorption
Oral absorption is saturable, and bioavailability is dose-dependent, decreasing with increasing dose. Peak plasma concentrations are reached within 2-3 hours.
Metabolism
Not significantly metabolized in humans; it is not an inducer or inhibitor of hepatic enzymes.
Side Effects
Contraindications
- Hypersensitivity to gabapentin or any component of the formulation.
- Acute pancreatitis caused by gabapentin.
Drug Interactions
Ethanol
Increased CNS depression when taken with alcohol.
Antacids
Concurrent use of antacids containing aluminum and magnesium can reduce the bioavailability of gabapentin. It is recommended to take gabapentin at least 2 hours after antacid administration.
Hydrocodone
Gabapentin has been shown to increase hydrocodone exposure.
Opioids (e.g., Morphine)
Concomitant use with opioids may increase gabapentin plasma concentrations and enhance CNS depressant effects. Close monitoring for somnolence and respiratory depression is advised.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include dizziness, somnolence, blurred vision, slurred speech, mild diarrhea, and lethargy. Management is supportive, and hemodialysis can effectively remove gabapentin from plasma.
Pregnancy & Lactation
Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Gabapentin is excreted into human milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to gabapentin or any component of the formulation.
- Acute pancreatitis caused by gabapentin.
Drug Interactions
Ethanol
Increased CNS depression when taken with alcohol.
Antacids
Concurrent use of antacids containing aluminum and magnesium can reduce the bioavailability of gabapentin. It is recommended to take gabapentin at least 2 hours after antacid administration.
Hydrocodone
Gabapentin has been shown to increase hydrocodone exposure.
Opioids (e.g., Morphine)
Concomitant use with opioids may increase gabapentin plasma concentrations and enhance CNS depressant effects. Close monitoring for somnolence and respiratory depression is advised.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include dizziness, somnolence, blurred vision, slurred speech, mild diarrhea, and lethargy. Management is supportive, and hemodialysis can effectively remove gabapentin from plasma.
Pregnancy & Lactation
Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Gabapentin is excreted into human milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture when stored under recommended conditions.
Availability
Pharmacies, Hospitals
Approval Status
FDA Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Gabapentin has undergone extensive clinical trials for its efficacy and safety in the treatment of partial seizures and postherpetic neuralgia. Studies have demonstrated its role as an effective adjunctive therapy for epilepsy and as a primary treatment for neuropathic pain.
Lab Monitoring
- Renal function should be monitored, especially in elderly patients and those with pre-existing renal impairment.
- Monitor for signs of pancreatitis (e.g., abdominal pain, nausea, vomiting) and consider amylase/lipase if suspected.
Doctor Notes
- Titrate gabapentin dosage slowly to minimize adverse effects, especially dizziness and somnolence.
- Monitor patients for changes in mood, behavior, and the emergence of suicidal ideation, particularly during initial therapy and dose adjustments.
- Adjust dose in renal impairment. For chewable tablets, advise patients on proper chewing technique.
Patient Guidelines
- Do not discontinue Gavista suddenly, as it may increase seizure frequency. Always consult your doctor before making any changes.
- Report any unusual changes in mood or behavior, including thoughts of self-harm, to your doctor immediately.
- This medication may cause dizziness or drowsiness. Avoid driving or operating heavy machinery until you know how it affects you.
- Chew the tablet thoroughly before swallowing to ensure proper absorption and effectiveness.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double a dose to make up for a missed one.
Driving Precautions
Gavista can cause dizziness, drowsiness, and impaired coordination. Patients should be advised not to drive or operate complex machinery until they have gained sufficient experience to gauge whether it adversely affects their ability.
Lifestyle Advice
- Avoid alcohol while taking Gavista, as it can worsen side effects like dizziness and drowsiness.
- Maintain good hydration by drinking plenty of fluids.
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