Medicine Information

Gavista

Name: Gavista
Brand: Gavista
Rating: 4.5 (117 reviews)

Suspension500 mgAnticonvulsants; Neuropathic pain agentsATC: N03AX12

Generic Name

Gabapentin

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
gavista 500 mg suspension	৳ 250.00	N/A

Description

Overview of the medicine

Gavista 500 mg Suspension contains Gabapentin, an anticonvulsant and neuropathic pain agent. It is used to treat partial seizures and neuropathic pain, such as postherpetic neuralgia.

Uses & Indications

Adjunctive therapy for partial seizures with or without secondary generalization in adults and children 3 years and older.

Management of postherpetic neuralgia in adults.

Treatment of neuropathic pain.

Dosage

Adults

For epilepsy: Initial dose 300 mg three times daily (TID) on Day 1, then titrated up to 900-3600 mg/day in 3 divided doses. For neuropathic pain: Initial 300 mg on Day 1, then titrated up to 1800-3600 mg/day in 3 divided doses.

Elderly

Start with a lower dose (e.g., 100 mg TID) and titrate slowly, monitoring for adverse effects and adjusting for renal function.

Renal_impairment

Dose adjustment required based on creatinine clearance (CrCl). For CrCl < 30 mL/min, significant dose reduction is needed. Hemodialysis patients require supplemental doses.

How to Take

Gavista suspension can be taken with or without food. Measure the dose accurately using a calibrated measuring device provided with the suspension. Do not stop taking it abruptly without consulting your doctor.

Mechanism of Action

Gabapentin's exact mechanism is unknown, but it is thought to modulate voltage-gated calcium channels, specifically binding to the alpha-2-delta subunit, which leads to reduced excitatory neurotransmitter release. It does not bind to GABA receptors directly.

Pharmacokinetics

Onset

Onset of effect varies, typically within days to weeks for full therapeutic benefit.

Excretion

Primarily excreted unchanged by the kidneys. Renal impairment significantly prolongs half-life.

Half life

Approximately 5 to 7 hours in adults with normal renal function.

Absorption

Oral bioavailability is not dose-proportional; it decreases with increasing dose due to saturable absorption.

Metabolism

Not significantly metabolized in humans; it does not induce or inhibit hepatic enzymes.

Side Effects

Contraindications

Hypersensitivity to Gabapentin or any component of the formulation.
Acute porphyria.

Drug Interactions

Ethanol/Alcohol

May potentiate the sedative effects of gabapentin.

Opioids (e.g., Morphine)

Concurrent use may increase gabapentin concentrations and increase the risk of CNS depression. Monitor for sedation and respiratory depression.

Antacids (e.g., aluminum and magnesium containing)

May reduce the bioavailability of gabapentin. Administer gabapentin at least 2 hours after antacid administration.

Storage

Store below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include dizziness, somnolence, blurred vision, dysarthria, and diarrhea. Management is primarily supportive; hemodialysis can be used for severe overdose in patients with renal impairment.

Pregnancy & Lactation

Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Gabapentin is excreted in human milk; caution should be exercised when administered to a nursing mother.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

100 mL bottle120 mL bottle

Shelf Life

Typically 24 to 36 months from the date of manufacture, when stored under recommended conditions.

Availability

Pharmacies, Hospitals

Approval Status

Approved by regulatory authorities (e.g., FDA, DGDA)

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Gabapentin has undergone extensive clinical trials demonstrating its efficacy and safety for the treatment of partial seizures and postherpetic neuralgia. Ongoing research continues to explore its potential in other neuropathic pain conditions.

Lab Monitoring

Renal function should be monitored, especially in elderly patients or those with pre-existing renal impairment.

Doctor Notes

Emphasize slow titration to minimize adverse effects, especially dizziness and somnolence.
Counsel patients on the risk of suicidal ideation and the importance of reporting any behavioral changes.
Adjust dose carefully in patients with renal impairment and monitor kidney function.

Patient Guidelines

Do not stop taking Gabapentin abruptly; it should be tapered gradually under medical supervision to avoid withdrawal symptoms.
Be aware of potential dizziness and drowsiness; avoid driving or operating machinery until you know how the medicine affects you.
Report any unusual mood changes, thoughts of self-harm, or behavioral changes to your doctor immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Gavista may cause dizziness, somnolence, and other central nervous system effects. Patients should be cautioned against driving or operating hazardous machinery until they have sufficient experience to determine whether Gavista adversely affects their ability to perform such tasks.

Lifestyle Advice

Avoid alcohol consumption while taking Gabapentin as it may increase side effects like dizziness and drowsiness.
Maintain a healthy lifestyle with regular exercise and a balanced diet.