Genac Plus
Generic Name
Paracetamol + Caffeine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| genac plus 75 mg injection | ৳ 15.00 | N/A |
Description
Overview of the medicine
Genac Plus is a combination medicine containing Paracetamol and Caffeine, used for rapid relief of various types of pain including headache, migraine, toothache, muscle pain, and fever. Caffeine enhances the pain-relieving effects of Paracetamol.
Uses & Indications
Dosage
Adults
1-2 tablets every 4-6 hours as needed, maximum 8 tablets in 24 hours.
Elderly
Same as adult dose, but caution for underlying conditions.
Renal_impairment
Dose adjustment may be necessary in severe renal impairment; consult a physician.
How to Take
Take orally with water. Can be taken with or without food. Do not exceed the recommended dose.
Mechanism of Action
Paracetamol works by inhibiting prostaglandin synthesis in the central nervous system, leading to analgesic and antipyretic effects. Caffeine acts as a CNS stimulant, vasoconstrictor, and enhances the analgesic effect of Paracetamol, possibly by increasing its absorption or direct action on pain pathways.
Pharmacokinetics
Onset
Pain relief usually within 15-30 minutes.
Excretion
Mainly via renal excretion as metabolites. Small amounts of unchanged Paracetamol are also excreted. Caffeine metabolites are excreted in urine.
Half life
Paracetamol: 1-4 hours (typically 2-3 hours). Caffeine: 3-7 hours.
Absorption
Both Paracetamol and Caffeine are rapidly and well absorbed from the gastrointestinal tract. Peak plasma concentrations of Paracetamol are reached within 30-60 minutes, and Caffeine within 30-120 minutes.
Metabolism
Paracetamol is primarily metabolized in the liver via glucuronidation and sulfation, with a small amount oxidized by cytochrome P450. Caffeine is extensively metabolized in the liver by CYP1A2.
Side Effects
Contraindications
- •Hypersensitivity to Paracetamol or Caffeine
- •Severe hepatic impairment
- •Severe renal impairment
- •G6PD deficiency
- •Children under 12 years (unless directed by physician)
Drug Interactions
Alcohol
Increased risk of liver toxicity with Paracetamol.
Warfarin
Increased anticoagulant effect, increased risk of bleeding.
Oral contraceptives
May increase caffeine levels.
Other Paracetamol-containing products
Increased risk of overdose.
Certain antibiotics (e.g., Fluoroquinolones)
May increase caffeine levels.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, abdominal pain, sweating, drowsiness, and liver damage. Seek immediate medical attention. Treatment involves gastric lavage, activated charcoal, and N-acetylcysteine for Paracetamol overdose.
Pregnancy & Lactation
Paracetamol is generally considered safe in pregnancy at recommended doses. Caffeine intake should be moderate. Consult a doctor before use during pregnancy and lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years from manufacturing date
Availability
Available in all pharmacies and drug stores in Bangladesh
Approval Status
Approved by DGDA
Patent Status
Generic (Patent expired)
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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