Glims
Generic Name
Glimepiride
Manufacturer
ACI Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| glims 4 mg tablet | ৳ 8.88 | ৳ 133.20 |
Description
Overview of the medicine
Glims 4 mg Tablet contains Glimepiride, an oral antidiabetic drug used to lower blood glucose levels in patients with type 2 diabetes mellitus when diet and exercise alone are not enough.
Uses & Indications
Dosage
Adults
Initially 1-2 mg once daily, administered with breakfast or the first main meal. Dose can be increased by 1-2 mg increments at 1-2 week intervals up to a maximum of 8 mg daily.
Elderly
Initial dose of 1 mg once daily; careful titration due to increased risk of hypoglycemia.
Renal_impairment
Starting dose 1 mg once daily. Close monitoring is essential.
How to Take
Oral administration. Take once daily with breakfast or the first main meal. Swallow the tablet whole with water. Do not crush or chew.
Mechanism of Action
Glimepiride primarily acts by stimulating insulin release from the pancreatic beta cells, thereby lowering blood glucose. It also increases sensitivity of peripheral tissues to insulin.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Mainly via urine (60%) and feces (40%) as metabolites.
Half life
Approximately 5-8 hours
Absorption
Well absorbed from the gastrointestinal tract; peak plasma concentrations reached in 2-3 hours.
Metabolism
Completely metabolized in the liver by CYP2C9 to two main metabolites.
Side Effects
Contraindications
- Hypersensitivity to Glimepiride or other sulfonylureas
- Diabetic ketoacidosis
- Type 1 Diabetes Mellitus
- Severe renal or hepatic impairment
Drug Interactions
NSAIDs
Can increase hypoglycemic effect.
Warfarin
May enhance or decrease anticoagulant effect.
Fluconazole
Increases Glimepiride's hypoglycemic effect.
Beta-blockers
May mask symptoms of hypoglycemia.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include severe hypoglycemia, headache, nausea, vomiting, sweating, tremor, and coma. Management involves immediate administration of glucose (oral or IV), monitoring blood glucose, and supportive care.
Pregnancy & Lactation
Pregnancy Category C. Not recommended during pregnancy; insulin is preferred. Avoid during lactation as it may be excreted in breast milk and cause hypoglycemia in infants.
Side Effects
Contraindications
- Hypersensitivity to Glimepiride or other sulfonylureas
- Diabetic ketoacidosis
- Type 1 Diabetes Mellitus
- Severe renal or hepatic impairment
Drug Interactions
NSAIDs
Can increase hypoglycemic effect.
Warfarin
May enhance or decrease anticoagulant effect.
Fluconazole
Increases Glimepiride's hypoglycemic effect.
Beta-blockers
May mask symptoms of hypoglycemia.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include severe hypoglycemia, headache, nausea, vomiting, sweating, tremor, and coma. Management involves immediate administration of glucose (oral or IV), monitoring blood glucose, and supportive care.
Pregnancy & Lactation
Pregnancy Category C. Not recommended during pregnancy; insulin is preferred. Avoid during lactation as it may be excreted in breast milk and cause hypoglycemia in infants.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacture date.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by FDA and DGDA
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have demonstrated Glimepiride's efficacy and safety in type 2 diabetes management, often in comparison to other sulfonylureas or metformin.
Lab Monitoring
- Fasting plasma glucose
- HbA1c
- Renal function (creatinine, GFR)
- Liver function tests (ALT, AST)
Doctor Notes
- Counsel patients on hypoglycemia symptoms and management.
- Emphasize lifestyle modifications (diet, exercise).
- Monitor renal and hepatic function, especially in elderly and those with comorbidities.
Patient Guidelines
- Take as directed by your doctor.
- Monitor your blood glucose regularly.
- Carry a source of sugar (e.g., candy, glucose tablets) for hypoglycemia.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember with a meal. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Caution is advised as Glimepiride can cause hypoglycemia, which may impair the ability to drive or operate machinery. Patients should be aware of hypoglycemic symptoms.
Lifestyle Advice
- Maintain a healthy diet.
- Engage in regular physical activity.
- Avoid excessive alcohol consumption.
- Manage stress levels.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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