Glipatab
Generic Name
Teneligliptin
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| glipatab 10 mg tablet | ৳ 16.00 | ৳ 160.00 |
Description
Overview of the medicine
Glipatab 10 mg Tablet contains Teneligliptin, an oral anti-diabetic drug used to improve glycemic control in adults with type 2 diabetes mellitus.
Uses & Indications
Dosage
Adults
Recommended dose is 10 mg once daily, taken orally. May be increased to 20 mg once daily if needed and tolerated.
Elderly
No dose adjustment required based solely on age.
Renal_impairment
No dose adjustment needed for mild to moderate renal impairment. For severe renal impairment or end-stage renal disease (ESRD), consider 5 mg once daily, but clinical data is limited.
How to Take
Take orally once daily, with or without food. It should be swallowed whole with water.
Mechanism of Action
Teneligliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It prevents the breakdown of incretin hormones (GLP-1 and GIP), thereby increasing their levels. This leads to glucose-dependent enhancement of insulin secretion and suppression of glucagon secretion, resulting in improved glycemic control.
Pharmacokinetics
Onset
Within hours of administration, sustained effect over 24 hours.
Excretion
Mainly excreted via kidneys (approx. 50%) and feces (approx. 50%).
Half life
Approximately 24 hours (effective half-life for DPP-4 inhibition).
Absorption
Rapidly absorbed after oral administration, peak plasma concentration reached within 1-2 hours.
Metabolism
Primarily metabolized by CYP3A4 and flavin-containing monooxygenase 3 (FMO3).
Side Effects
Contraindications
- Hypersensitivity to Teneligliptin or any component of the tablet
- Type 1 diabetes mellitus
- Diabetic ketoacidosis
Drug Interactions
Insulin or Sulfonylureas
Increased risk of hypoglycemia, may require dose adjustment of insulin/sulfonylureas.
CYP3A4/FMO3 inhibitors (e.g., Ketoconazole, Ritonavir)
May increase Teneligliptin plasma concentrations.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally consistent with the known side effects. Management is symptomatic and supportive, including gastric lavage and observation.
Pregnancy & Lactation
Pregnancy Category B. Limited data in pregnant women. Use only if potential benefit justifies the potential risk to the fetus. It is not known whether Teneligliptin is excreted in human milk. Exercise caution when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to Teneligliptin or any component of the tablet
- Type 1 diabetes mellitus
- Diabetic ketoacidosis
Drug Interactions
Insulin or Sulfonylureas
Increased risk of hypoglycemia, may require dose adjustment of insulin/sulfonylureas.
CYP3A4/FMO3 inhibitors (e.g., Ketoconazole, Ritonavir)
May increase Teneligliptin plasma concentrations.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally consistent with the known side effects. Management is symptomatic and supportive, including gastric lavage and observation.
Pregnancy & Lactation
Pregnancy Category B. Limited data in pregnant women. Use only if potential benefit justifies the potential risk to the fetus. It is not known whether Teneligliptin is excreted in human milk. Exercise caution when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies, hospitals
Approval Status
Approved in various countries, including Japan and Bangladesh (DGDA)
Patent Status
Patent expired/expiring in some regions, allowing generics. Still under patent in others.
Clinical Trials
Extensive clinical trials have demonstrated efficacy and safety in patients with type 2 diabetes, both as monotherapy and in combination therapies.
Lab Monitoring
- HbA1c levels
- Fasting and postprandial glucose levels
- Renal function (eGFR) periodically
Doctor Notes
- Consider dose adjustment for severe renal impairment.
- Monitor for signs of pancreatitis.
- Educate patients on hypoglycemia symptoms, especially when combined with insulin/sulfonylureas.
Patient Guidelines
- Take medicine as prescribed by your doctor.
- Do not stop taking the medicine without consulting your doctor.
- Report any unusual side effects immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at once to make up for a missed dose.
Driving Precautions
Glipatab is unlikely to affect the ability to drive or operate machinery. However, if symptoms of hypoglycemia (e.g., dizziness) occur, caution is advised.
Lifestyle Advice
- Maintain a healthy diet and regular exercise.
- Monitor blood sugar levels regularly.
- Avoid smoking and excessive alcohol consumption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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