Glipita
Generic Name
Vildagliptin
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| glipita 50 mg tablet | ৳ 13.00 | ৳ 195.00 |
Description
Overview of the medicine
Glipita-50 mg Tablet contains Vildagliptin, an oral anti-hyperglycemic agent used to manage blood sugar levels in adults with type 2 diabetes mellitus.
Uses & Indications
Dosage
Adults
The recommended dose of Vildagliptin is 50 mg once or twice daily, depending on the combination therapy and individual patient response. Maximum daily dose is 100 mg.
Elderly
No dose adjustment is necessary in elderly patients.
Renal_impairment
For moderate to severe renal impairment (CrCl < 50 mL/min) or ESRD, the recommended dose is 50 mg once daily.
How to Take
Oral administration. Can be taken with or without food. To be swallowed whole with water.
Mechanism of Action
Vildagliptin inhibits the enzyme Dipeptidyl Peptidase-4 (DPP-4), which normally inactivates incretin hormones (GLP-1 and GIP). By inhibiting DPP-4, vildagliptin increases the levels of active incretin hormones, leading to enhanced glucose-dependent insulin secretion from pancreatic beta cells and reduced glucagon secretion from alpha cells, thus lowering blood glucose levels.
Pharmacokinetics
Onset
Within hours of administration, sustained for 24 hours.
Excretion
Primarily renal (85% as metabolites, 23% as unchanged drug); 15% through feces.
Half life
Approximately 3 hours.
Absorption
Rapidly absorbed. Peak plasma concentrations are reached in 1.7-2.5 hours. Absolute bioavailability is 85%.
Metabolism
Primarily hydrolyzed by peptidases to an inactive metabolite (LAY151). CYP450 enzymes are not involved.
Side Effects
Contraindications
- Hypersensitivity to Vildagliptin or any of the excipients.
- Patients with severe hepatic impairment (ALT or AST > 3 x ULN before treatment).
Drug Interactions
ACE Inhibitors
Increased risk of angioedema when co-administered.
Thiazides, Corticosteroids, Thyroid products
May reduce the hypoglycemic effect of Vildagliptin, requiring careful monitoring.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include muscle pain, mild and transient paresthesia, fever, edema. Management is supportive; Vildagliptin is not removable by hemodialysis.
Pregnancy & Lactation
Not recommended during pregnancy due to insufficient data. Advise against breastfeeding as it is unknown if Vildagliptin is excreted in human milk.
Side Effects
Contraindications
- Hypersensitivity to Vildagliptin or any of the excipients.
- Patients with severe hepatic impairment (ALT or AST > 3 x ULN before treatment).
Drug Interactions
ACE Inhibitors
Increased risk of angioedema when co-administered.
Thiazides, Corticosteroids, Thyroid products
May reduce the hypoglycemic effect of Vildagliptin, requiring careful monitoring.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include muscle pain, mild and transient paresthesia, fever, edema. Management is supportive; Vildagliptin is not removable by hemodialysis.
Pregnancy & Lactation
Not recommended during pregnancy due to insufficient data. Advise against breastfeeding as it is unknown if Vildagliptin is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture.
Availability
Available in pharmacies and hospitals.
Approval Status
Approved by regulatory authorities for use in type 2 diabetes.
Patent Status
Generic available, active ingredient is likely off-patent.
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of vildagliptin in improving glycemic control in patients with type 2 diabetes mellitus.
Lab Monitoring
- Liver function tests (ALT, AST) should be performed prior to initiation of Vildagliptin treatment, at 3-month intervals for the first year, and periodically thereafter.
- Renal function should be assessed before starting treatment and periodically during treatment.
Doctor Notes
- Educate patients on the importance of diet, exercise, and adherence to medication for optimal glycemic control.
- Advise patients to report any symptoms of pancreatitis (e.g., severe abdominal pain) or liver injury (e.g., jaundice, dark urine).
- Consider dose adjustment in patients with moderate to severe renal impairment.
Patient Guidelines
- Take Glipita-50 mg Tablet exactly as prescribed by your doctor.
- Do not stop taking this medication without consulting your doctor, even if you feel well.
- Report any unusual or severe side effects to your doctor immediately, especially signs of liver problems or pancreatitis.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Vildagliptin has minor influence on the ability to drive and use machines. Patients experiencing dizziness should exercise caution.
Lifestyle Advice
- Maintain a healthy diet and regular exercise routine as advised by your healthcare provider.
- Monitor your blood glucose levels regularly as instructed.
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Global Brand Names
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