Gloxen
Generic Name
gloxen-250-mg-tablet
Manufacturer
Opsonin Pharma Limited
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| gloxen 250 mg tablet | ৳ 4.00 | ৳ 40.00 |
Description
Overview of the medicine
Gatifloxacin is a broad-spectrum fluoroquinolone antibiotic used to treat bacterial infections in various parts of the body.
Uses & Indications
Dosage
Adults
Typically 200-400 mg once daily, depending on the infection type and severity. For 250mg, usually 250 mg once daily for 5-10 days.
Elderly
No specific dosage adjustment based on age alone; monitor renal function.
Renal_impairment
For creatinine clearance < 40 ml/min, dose adjustment is required (e.g., 200 mg every 24 hours).
How to Take
Gloxen-250 mg tablet should be taken orally with or without food. Do not take within 2 hours of antacids (containing aluminum, magnesium, or sucralfate), iron supplements, or multivitamins containing zinc, as they can significantly reduce absorption.
Mechanism of Action
Gatifloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination, leading to bacterial cell death.
Pharmacokinetics
Onset
Varies by infection type, typically within hours to days for clinical improvement.
Excretion
Primarily excreted unchanged in urine (about 70% of a dose), with a smaller portion via feces.
Half life
Approximately 7-14 hours, enabling once-daily dosing.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations (Cmax) reached within 1-2 hours. Absolute bioavailability is approximately 96%.
Metabolism
Minimally metabolized by the liver; less than 1% of the dose is metabolized.
Side Effects
Contraindications
- •Hypersensitivity to gatifloxacin or other fluoroquinolones
- •History of tendinitis or tendon rupture associated with fluoroquinolone use
- •History of myasthenia gravis
Drug Interactions
Warfarin
Increased anticoagulant effect; monitor INR closely.
Corticosteroids
Increased risk of tendon rupture when co-administered.
Antacids, iron, zinc-containing products
Reduced absorption of gatifloxacin. Administer gatifloxacin at least 2 hours before or 4 hours after these agents.
Drugs that prolong QT interval (e.g., Class IA and III antiarrhythmics, tricyclic antidepressants, macrolides)
Increased risk of QT prolongation and arrhythmias.
Storage
Store in a cool, dry place, below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. Gastric lavage may be considered. Hemodialysis and peritoneal dialysis are minimally effective in removing gatifloxacin from the body.
Pregnancy & Lactation
Pregnancy Category C. Gatifloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted into breast milk; therefore, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from the manufacturing date, consult packaging for exact date.
Availability
Pharmacies
Approval Status
Approved by DGDA
Patent Status
Generic available
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Global Brand Names
International brand names for this medicine
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