Glucodip
Generic Name
Glucodipflozin
Manufacturer
MediCorp Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| glucodip 100 mg tablet | ৳ 27.00 | ৳ 270.00 |
Description
Overview of the medicine
Glucodip 100 mg Tablet contains Glucodipflozin, an oral antidiabetic medication belonging to the SGLT2 inhibitor class. It is used to improve glycemic control in adults with type 2 diabetes mellitus, and also indicated for heart failure and chronic kidney disease.
Uses & Indications
Dosage
Adults
The recommended dose of Glucodip is 100 mg orally once daily, taken in the morning, with or without food. Adjustments may be made based on glycemic control and tolerability.
Elderly
No dose adjustment is required based on age alone. However, renal function should be assessed, especially in elderly patients, as they are more likely to have impaired renal function.
Renal_impairment
For patients with eGFR ≥45 mL/min/1.73 m², no dose adjustment is needed. Initiation is not recommended for eGFR <25 mL/min/1.73 m². For eGFR 25 to <45 mL/min/1.73 m², assess benefits and risks. Clinical judgment advised for doses over 10 mg/day in moderate to severe impairment.
How to Take
Take Glucodip 100 mg Tablet orally once daily in the morning, with or without food. Swallow the tablet whole with water. Do not crush, cut, or chew it.
Mechanism of Action
Glucodipflozin works by inhibiting the sodium-glucose co-transporter 2 (SGLT2) in the renal proximal tubules. This reduces glucose reabsorption from the glomerular filtrate and lowers the renal threshold for glucose, leading to increased urinary glucose excretion and a reduction in blood glucose levels.
Pharmacokinetics
Onset
Glucose lowering effects are observed within a few hours of administration.
Excretion
Excreted primarily via the kidneys (approximately 75% in urine as metabolites) and about 20% in feces.
Half life
Approximately 10-14 hours, allowing for once-daily dosing.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations (Tmax) reached within 1-2 hours. Bioavailability is high.
Metabolism
Primarily metabolized in the liver via glucuronidation by UGT1A9 to an inactive metabolite.
Side Effects
Contraindications
- Hypersensitivity to Glucodipflozin or any excipients in the tablet.
- Patients with severe renal impairment (eGFR <25 mL/min/1.73 m²) who are on dialysis or have end-stage renal disease, as efficacy is reduced.
- Diabetic ketoacidosis (DKA) at presentation.
Drug Interactions
Lithium
SGLT2 inhibitors may decrease serum lithium concentrations. Monitor lithium levels frequently.
Diuretics
Increased risk of dehydration and hypotension when co-administered with diuretics.
Insulin and Insulin Secretagogues (e.g., Sulfonylureas)
Increased risk of hypoglycemia when co-administered with insulin or insulin secretagogues. A lower dose of insulin or the sulfonylurea may be required.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose may lead to dehydration, hypotension, and electrolyte imbalances. Management involves supportive measures, rehydration, and monitoring of vital signs and electrolyte levels. Glucodipflozin is minimally dialyzable.
Pregnancy & Lactation
Not recommended during pregnancy, especially during the second and third trimesters, due to potential adverse effects on renal development in the fetus. Not recommended during breastfeeding, as it is unknown if Glucodipflozin is excreted in human milk.
Side Effects
Contraindications
- Hypersensitivity to Glucodipflozin or any excipients in the tablet.
- Patients with severe renal impairment (eGFR <25 mL/min/1.73 m²) who are on dialysis or have end-stage renal disease, as efficacy is reduced.
- Diabetic ketoacidosis (DKA) at presentation.
Drug Interactions
Lithium
SGLT2 inhibitors may decrease serum lithium concentrations. Monitor lithium levels frequently.
Diuretics
Increased risk of dehydration and hypotension when co-administered with diuretics.
Insulin and Insulin Secretagogues (e.g., Sulfonylureas)
Increased risk of hypoglycemia when co-administered with insulin or insulin secretagogues. A lower dose of insulin or the sulfonylurea may be required.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose may lead to dehydration, hypotension, and electrolyte imbalances. Management involves supportive measures, rehydration, and monitoring of vital signs and electrolyte levels. Glucodipflozin is minimally dialyzable.
Pregnancy & Lactation
Not recommended during pregnancy, especially during the second and third trimesters, due to potential adverse effects on renal development in the fetus. Not recommended during breastfeeding, as it is unknown if Glucodipflozin is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities for Type 2 Diabetes Mellitus
Patent Status
Under patent protection in most regions, generic versions emerging in some
WHO Essential Medicine
YesClinical Trials
Extensive clinical trial programs have demonstrated Glucodipflozin's efficacy in glycemic control and its cardiovascular and renal benefits. Key trials include studies similar to DECLARE-TIMI 58 and DAPA-CKD, which confirmed its role beyond glycemic control.
Lab Monitoring
- Renal function (e.g., eGFR, serum creatinine) should be assessed before initiating Glucodip and periodically thereafter.
- Glycemic control (e.g., HbA1c, fasting plasma glucose) should be monitored regularly.
- Lipid profile (less common but considered in some patients).
Doctor Notes
- Educate patients on symptoms of DKA and genital mycotic infections.
- Assess renal function before initiation and periodically during treatment.
- Consider risk factors for volume depletion and hypotension, especially in elderly or diuretic-treated patients.
Patient Guidelines
- Take Glucodip exactly as prescribed by your doctor.
- Stay well-hydrated, especially in hot weather or during physical activity.
- Practice good personal hygiene to reduce the risk of genital mycotic infections.
- Be aware of symptoms of DKA (e.g., nausea, vomiting, abdominal pain, fruity breath) and seek immediate medical attention if they occur.
- Inform your doctor if you are undergoing surgery or experiencing severe illness.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Glucodip is unlikely to affect your ability to drive or operate machinery when used alone. However, if used in combination with insulin or sulfonylureas, it may increase the risk of hypoglycemia, which could impair driving ability. Exercise caution.
Lifestyle Advice
- Maintain a healthy, balanced diet as advised by your healthcare provider.
- Engage in regular physical activity.
- Monitor your blood glucose levels regularly as instructed.
- Avoid excessive alcohol consumption.
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