Gluconor
Generic Name
Glimepiride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| gluconor 1 mg tablet | ৳ 6.00 | ৳ 60.00 |
Description
Overview of the medicine
Gluconor 1 mg Tablet is an oral antidiabetic medicine used to lower blood glucose levels in patients with type 2 diabetes mellitus. It belongs to the sulfonylurea class of drugs.
Uses & Indications
Dosage
Adults
Initial dose is 1-2 mg once daily, taken with breakfast or first main meal. Max dose: 8 mg/day.
Elderly
Start with 1 mg once daily and titrate carefully based on glucose monitoring.
Renal_impairment
Initial dose of 1 mg once daily; dosage adjustments required based on renal function and glucose monitoring. Avoid in severe renal impairment.
How to Take
Take orally, once daily with breakfast or the first main meal. Swallow whole with water. Do not chew or crush.
Mechanism of Action
Glimepiride stimulates insulin release from the pancreatic beta cells by binding to the sulfonylurea receptor (SUR1) on the cell surface, leading to closure of ATP-sensitive potassium channels and subsequent depolarization, which opens voltage-gated calcium channels and triggers insulin secretion.
Pharmacokinetics
Onset
Within 2-3 hours
Excretion
Approximately 60% of the dose is excreted in the urine and 40% in the feces. Both metabolites are non-active.
Half life
5-8 hours
Absorption
Rapidly and completely absorbed from the gastrointestinal tract. Peak plasma concentrations reached within 2-3 hours.
Metabolism
Completely metabolized in the liver by CYP2C9 to two major metabolites, a cyclohexylhydroxy methyl derivative and a carboxyl derivative.
Side Effects
Contraindications
- Hypersensitivity to glimepiride or other sulfonylureas or sulfonamides.
- Diabetic ketoacidosis.
- Type 1 diabetes mellitus.
- Severe renal or hepatic impairment.
- Pregnancy and lactation.
Drug Interactions
Warfarin
Glimepiride may potentiate the effect of warfarin.
Beta-blockers, ACE inhibitors, MAO inhibitors, NSAIDs
May enhance the hypoglycemic effect of glimepiride.
Thiazide diuretics, Corticosteroids, Thyroid hormones
May decrease the hypoglycemic effect, leading to hyperglycemia.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms: Hypoglycemia (sweating, tremor, hunger, confusion, dizziness). Management: Administer glucose orally or intravenously. Monitor blood glucose and vital signs closely.
Pregnancy & Lactation
Contraindicated during pregnancy and lactation. Insulin is generally preferred for blood glucose control during pregnancy. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to glimepiride or other sulfonylureas or sulfonamides.
- Diabetic ketoacidosis.
- Type 1 diabetes mellitus.
- Severe renal or hepatic impairment.
- Pregnancy and lactation.
Drug Interactions
Warfarin
Glimepiride may potentiate the effect of warfarin.
Beta-blockers, ACE inhibitors, MAO inhibitors, NSAIDs
May enhance the hypoglycemic effect of glimepiride.
Thiazide diuretics, Corticosteroids, Thyroid hormones
May decrease the hypoglycemic effect, leading to hyperglycemia.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms: Hypoglycemia (sweating, tremor, hunger, confusion, dizziness). Management: Administer glucose orally or intravenously. Monitor blood glucose and vital signs closely.
Pregnancy & Lactation
Contraindicated during pregnancy and lactation. Insulin is generally preferred for blood glucose control during pregnancy. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
Clinical Trials
Extensive clinical trials have established the efficacy and safety of glimepiride in type 2 diabetes management, including studies on cardiovascular outcomes.
Lab Monitoring
- Fasting plasma glucose
- HbA1c
- Renal function tests (e.g., creatinine, eGFR)
- Liver function tests
Doctor Notes
- Advise patients on hypoglycemia recognition and management.
- Emphasize adherence to diet and exercise.
- Regular monitoring of blood glucose and HbA1c is crucial.
- Educate on potential drug interactions.
Patient Guidelines
- Follow diet and exercise recommendations strictly.
- Monitor blood glucose regularly as advised by your doctor.
- Be aware of symptoms of hypoglycemia and how to manage them.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it's almost time for your next dose. Do not double the dose to make up for a missed one.
Driving Precautions
May cause hypoglycemia, which can impair ability to drive or operate machinery. Patients should be aware of hypoglycemic symptoms.
Lifestyle Advice
- Maintain a balanced diet.
- Engage in regular physical activity.
- Avoid smoking.
- Limit alcohol intake.
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