Gluconor
Generic Name
Glimepiride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| gluconor 2 mg tablet | ৳ 9.00 | ৳ 90.00 |
Description
Overview of the medicine
Gluconor 2 mg Tablet contains Glimepiride, an oral antidiabetic drug in the sulfonylurea class. It is used to lower blood glucose levels in patients with type 2 diabetes mellitus when diet and exercise alone are not sufficient.
Uses & Indications
Dosage
Adults
Initially 1-2 mg once daily, administered with breakfast or the first main meal. Dosage can be increased gradually in increments of 1-2 mg at 1-2 week intervals based on blood glucose response, up to a maximum of 8 mg once daily.
Elderly
Initial dose of 1 mg once daily, titrated carefully.
Renal_impairment
Initial dose of 1 mg once daily. For severe renal impairment (CrCl < 22 mL/min), initial dose of 1 mg and careful titration is recommended.
How to Take
Take orally once daily with breakfast or the first main meal of the day. Swallow the tablet whole with water. Do not crush or chew.
Mechanism of Action
Glimepiride primarily lowers blood glucose by stimulating the release of insulin from pancreatic beta cells. It also increases the sensitivity of peripheral tissues to insulin.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Mainly excreted in urine (approx. 60%) and feces (approx. 40%) as metabolites.
Half life
Approximately 5-9 hours
Absorption
Well absorbed from the gastrointestinal tract, with peak plasma concentrations occurring 2-3 hours after oral administration.
Metabolism
Extensively metabolized in the liver by CYP2C9 to two main metabolites, a cyclohexylhydroxy derivative and a carboxyl derivative.
Side Effects
Contraindications
- Hypersensitivity to glimepiride or other sulfonylureas
- Diabetic ketoacidosis (with or without coma)
- Type 1 diabetes mellitus
- Severe renal or hepatic impairment (without dose adjustment)
Drug Interactions
NSAIDs, salicylates, sulfonamides, chloramphenicol, coumarins, probenecid, monoamine oxidase inhibitors, beta-blockers, alcohol
May potentiate the hypoglycemic effect of glimepiride.
Thiazides, corticosteroids, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blockers
May reduce the hypoglycemic effect of glimepiride, leading to hyperglycemia.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include hypoglycemia (sweating, tremor, hunger, confusion, coma). Management involves immediate glucose administration (oral glucose for conscious patients, IV glucose for unconscious patients), close monitoring, and potentially hospitalization.
Pregnancy & Lactation
Pregnancy Category C. Not recommended during pregnancy as insulin is generally preferred. Avoid during lactation; an alternative should be considered or breastfeeding should be discontinued.
Side Effects
Contraindications
- Hypersensitivity to glimepiride or other sulfonylureas
- Diabetic ketoacidosis (with or without coma)
- Type 1 diabetes mellitus
- Severe renal or hepatic impairment (without dose adjustment)
Drug Interactions
NSAIDs, salicylates, sulfonamides, chloramphenicol, coumarins, probenecid, monoamine oxidase inhibitors, beta-blockers, alcohol
May potentiate the hypoglycemic effect of glimepiride.
Thiazides, corticosteroids, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blockers
May reduce the hypoglycemic effect of glimepiride, leading to hyperglycemia.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include hypoglycemia (sweating, tremor, hunger, confusion, coma). Management involves immediate glucose administration (oral glucose for conscious patients, IV glucose for unconscious patients), close monitoring, and potentially hospitalization.
Pregnancy & Lactation
Pregnancy Category C. Not recommended during pregnancy as insulin is generally preferred. Avoid during lactation; an alternative should be considered or breastfeeding should be discontinued.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture.
Availability
Available in pharmacies nationwide
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of glimepiride in reducing HbA1c and fasting plasma glucose levels in patients with type 2 diabetes. Studies have also evaluated its use in combination therapy.
Lab Monitoring
- Fasting blood glucose (FBG)
- HbA1c levels
- Renal function tests
- Liver function tests
- Blood counts (periodically)
Doctor Notes
- Emphasize patient education on hypoglycemia recognition and management.
- Regularly assess renal and hepatic function, especially in elderly or co-morbid patients.
- Consider combination therapy early if monotherapy fails to achieve glycemic targets.
Patient Guidelines
- Take as directed by your doctor, preferably with breakfast.
- Do not skip meals while taking this medicine.
- Be aware of symptoms of hypoglycemia and how to treat it (e.g., consume glucose tablets or sugary drinks).
- Regularly monitor blood glucose levels as advised.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Patients should be aware of the risk of hypoglycemia, which may impair their ability to drive or operate machinery. If hypoglycemic symptoms occur, avoid driving.
Lifestyle Advice
- Follow a balanced diet and regular exercise regimen.
- Maintain a healthy weight.
- Limit alcohol intake, as it can increase the risk of hypoglycemia.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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