Handirub
Generic Name
Methyl Salicylate + Menthol + Camphor
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
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Description
Overview of the medicine
Handirub is a topical analgesic rub formulated with methyl salicylate, menthol, and camphor. It is used for the temporary relief of minor aches and pains of muscles and joints associated with simple backache, arthritis, strains, bruises, and sprains.
Uses & Indications
Dosage
Adults
Apply to the affected area 2-3 times daily. Gently massage until the rub is absorbed.
Elderly
No specific dosage adjustment required. Use as for adults.
Renal_impairment
Not applicable for topical use as systemic absorption is minimal.
How to Take
For external use only. Apply a thin layer to the clean, dry affected area. Do not apply to broken, irritated skin, or open wounds. Wash hands thoroughly after application.
Mechanism of Action
Methyl salicylate acts as a topical NSAID, providing local analgesic and anti-inflammatory effects. Menthol and camphor are counterirritants that produce a sensation of warmth or coolness, distracting from pain and increasing local blood flow. This combined action helps to relieve muscle and joint discomfort.
Pharmacokinetics
Onset
Rapid, typically within a few minutes of application.
Excretion
Mainly local effect; systemically absorbed salicylates are excreted renally.
Half life
Systemic half-life of salicylates varies (2-4 hours for low doses), but not clinically significant for topical use.
Absorption
Minimal systemic absorption occurs through the skin, primarily localized action. Salicylates can be absorbed systemically to a small extent.
Metabolism
Locally metabolized in the skin and if absorbed, by hepatic enzymes for salicylates.
Side Effects
Contraindications
- Hypersensitivity to any of the ingredients (methyl salicylate, menthol, camphor, or other excipients)
- Application on broken, irritated, or damaged skin
- Children under 2 years of age (due to camphor and menthol content)
- Asthma or other respiratory conditions sensitive to menthol or camphor vapors
Drug Interactions
Oral Anticoagulants (e.g., Warfarin)
Though systemic absorption is minimal, large doses of topical salicylates over prolonged periods or large areas could theoretically increase the risk of bleeding. Use with caution.
Storage
Store below 30°C. Protect from direct sunlight, heat, and moisture. Keep out of reach of children.
Overdose
Topical overdose is unlikely to cause serious systemic effects. However, excessive application may lead to increased skin irritation. In case of accidental ingestion, seek immediate medical attention, as it can be toxic.
Pregnancy & Lactation
Consult a doctor before use during pregnancy or lactation. Use with caution, especially on large body areas or for prolonged periods, due to potential systemic absorption of salicylates.
Side Effects
Contraindications
- Hypersensitivity to any of the ingredients (methyl salicylate, menthol, camphor, or other excipients)
- Application on broken, irritated, or damaged skin
- Children under 2 years of age (due to camphor and menthol content)
- Asthma or other respiratory conditions sensitive to menthol or camphor vapors
Drug Interactions
Oral Anticoagulants (e.g., Warfarin)
Though systemic absorption is minimal, large doses of topical salicylates over prolonged periods or large areas could theoretically increase the risk of bleeding. Use with caution.
Storage
Store below 30°C. Protect from direct sunlight, heat, and moisture. Keep out of reach of children.
Overdose
Topical overdose is unlikely to cause serious systemic effects. However, excessive application may lead to increased skin irritation. In case of accidental ingestion, seek immediate medical attention, as it can be toxic.
Pregnancy & Lactation
Consult a doctor before use during pregnancy or lactation. Use with caution, especially on large body areas or for prolonged periods, due to potential systemic absorption of salicylates.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date, when stored properly.
Availability
Available in pharmacies and supermarkets
Approval Status
Approved by regulatory authorities (e.g., DGDA)
Patent Status
Generic / Patent Expired
Clinical Trials
Established active ingredients, efficacy is well-documented for symptomatic relief. Specific new trials for 'Handirub' brand are generally not required for market entry of such formulations.
Lab Monitoring
- Not routinely required for typical topical use.
Doctor Notes
- Educate patients on proper application technique and warning signs (e.g., severe irritation, systemic symptoms).
- Advise against use on open wounds or irritated skin.
- Consider underlying causes of pain if symptoms persist or worsen.
Patient Guidelines
- For external use only. Avoid contact with eyes, mouth, nose, and other mucous membranes.
- Do not apply to wounds, irritated skin, or damaged skin.
- Do not bandage tightly or apply heat to the treated area.
- Wash hands thoroughly after use.
Missed Dose Advice
If a dose is missed, apply it as soon as you remember. Do not apply extra rub to compensate for a missed dose.
Driving Precautions
Handirub is a topical product and is not expected to affect the ability to drive or operate machinery.
Lifestyle Advice
- For chronic pain, incorporate light exercise and stretching into your routine.
- Maintain good posture to alleviate back and joint stress.
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