Hepaximin
Generic Name
Rifaximin
Manufacturer
ACI Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| hepaximin 200 mg tablet | ৳ 22.00 | ৳ 220.00 |
Description
Overview of the medicine
Hepaximin 200 mg Tablet contains Rifaximin, a non-systemic antibiotic used to treat various gastrointestinal infections and conditions. It acts locally in the gut due to its minimal systemic absorption.
Uses & Indications
Dosage
Adults
For Traveler's Diarrhea: 200 mg orally three times daily for 3 days. For other indications, follow doctor's advice.
Elderly
No dosage adjustment is needed for elderly patients.
Renal_impairment
No dosage adjustment is recommended for patients with renal impairment due to minimal systemic absorption.
How to Take
Take Hepaximin 200 mg Tablet orally with or without food, as directed by your doctor. Swallow the tablet whole with a glass of water.
Mechanism of Action
Rifaximin inhibits bacterial RNA synthesis by binding to bacterial DNA-dependent RNA polymerase. Its poor systemic absorption allows it to act locally in the gastrointestinal tract, reducing bacterial load where desired.
Pharmacokinetics
Onset
Rapid for local antibacterial action in the gut; symptoms relief for traveler's diarrhea typically within 24-48 hours.
Excretion
Primarily excreted unchanged in the feces (>96% of the dose) due to minimal systemic absorption.
Half life
Plasma half-life is short (approximately 5-6 hours), but its local action persists within the gut.
Absorption
Very low systemic absorption (<0.4%) after oral administration, ensuring high local gut concentration.
Metabolism
Minimally metabolized by CYP3A4, primarily in the liver, with very limited systemic exposure.
Side Effects
Contraindications
- Hypersensitivity to Rifaximin, rifamycin antimicrobial agents, or any component of the formulation.
- Severe diarrheal disease complicated by fever or blood in the stool.
Drug Interactions
Cyclosporine
Concurrent administration with cyclosporine significantly increases systemic exposure to rifaximin. Monitor for systemic effects of rifaximin.
P-glycoprotein Inhibitors/Inducers
Co-administration with P-glycoprotein inhibitors (e.g., cyclosporine) may increase systemic exposure, while inducers (e.g., rifampin) may decrease it. However, clinical significance is minimal due to low systemic absorption.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, no specific antidote is available. Management should be symptomatic and supportive. Contact a poison control center or emergency services immediately.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution is advised during lactation; consult your doctor.
Side Effects
Contraindications
- Hypersensitivity to Rifaximin, rifamycin antimicrobial agents, or any component of the formulation.
- Severe diarrheal disease complicated by fever or blood in the stool.
Drug Interactions
Cyclosporine
Concurrent administration with cyclosporine significantly increases systemic exposure to rifaximin. Monitor for systemic effects of rifaximin.
P-glycoprotein Inhibitors/Inducers
Co-administration with P-glycoprotein inhibitors (e.g., cyclosporine) may increase systemic exposure, while inducers (e.g., rifampin) may decrease it. However, clinical significance is minimal due to low systemic absorption.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, no specific antidote is available. Management should be symptomatic and supportive. Contact a poison control center or emergency services immediately.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution is advised during lactation; consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Varies by country and indication (some patents expired, some active)
Clinical Trials
Rifaximin has undergone extensive clinical trials supporting its efficacy and safety for approved indications, including traveler's diarrhea, hepatic encephalopathy, and IBS-D.
Lab Monitoring
- Routine laboratory monitoring is generally not required due to minimal systemic absorption.
Doctor Notes
- Emphasize Rifaximin's non-systemic nature; it is primarily active within the gut lumen and has limited utility for systemic infections.
- Advise patients on appropriate hydration, especially in cases of severe diarrhea.
Patient Guidelines
- Complete the full course of treatment as prescribed by your doctor, even if symptoms improve.
- Do not use Hepaximin if your diarrhea is severe and accompanied by fever or blood in your stool.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Hepaximin is generally not expected to affect the ability to drive or operate machinery. However, if you experience dizziness or any other side effect that may impair your ability, avoid these activities.
Lifestyle Advice
- Maintain adequate hydration, especially during traveler's diarrhea, to prevent dehydration.
- Practice good hygiene to prevent the spread of infections.
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