Hepaximin
Generic Name
Rifaximin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| hepaximin 550 mg tablet | ৳ 55.00 | ৳ 550.00 |
Description
Overview of the medicine
Hepaximin 550 mg Tablet contains Rifaximin, a non-systemic antibiotic that works locally in the gastrointestinal tract. It is primarily used to treat hepatic encephalopathy, irritable bowel syndrome with diarrhea (IBS-D), and traveler's diarrhea.
Uses & Indications
Dosage
Adults
For Hepatic Encephalopathy: 550 mg orally two times a day. For IBS-D: 550 mg orally three times a day for 14 days, may be repeated twice.
Elderly
No dosage adjustment is generally required for elderly patients.
Renal_impairment
No dosage adjustment recommended in patients with renal impairment.
How to Take
May be taken with or without food. Swallow the tablet whole with a glass of water.
Mechanism of Action
Rifaximin is a rifamycin derivative antibiotic that inhibits bacterial RNA synthesis by binding to the beta-subunit of bacterial DNA-dependent RNA polymerase. Due to its poor systemic absorption, it acts locally in the gut to reduce ammonia-producing bacteria in hepatic encephalopathy, and to modify gut flora in IBS-D.
Pharmacokinetics
Onset
Varies by indication; for hepatic encephalopathy, symptomatic improvement may be seen within days.
Excretion
Primarily excreted unchanged in feces (96.9% of dose). Urinary excretion is negligible.
Half life
Approximately 5-6 hours in healthy volunteers, longer in hepatic impairment.
Absorption
Poorly absorbed systemically (<0.4%). Peak plasma concentrations are very low.
Metabolism
Minimally metabolized; some metabolism by hepatic CYP3A4, but limited due to poor absorption.
Side Effects
Contraindications
- Hypersensitivity to Rifaximin, any rifamycin antimicrobial agent, or any component of the formulation
- Diarrhea complicated by fever and/or bloody stool
Drug Interactions
Warfarin
Potential to alter gut flora and affect vitamin K production, which may influence INR. Monitor INR closely.
P-glycoprotein inhibitors (e.g., cyclosporine)
May significantly increase systemic exposure to rifaximin due to increased absorption.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. Symptomatic and supportive treatment is recommended in case of overdose.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs the risk. Excretion into breast milk is unknown; caution advised during breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to Rifaximin, any rifamycin antimicrobial agent, or any component of the formulation
- Diarrhea complicated by fever and/or bloody stool
Drug Interactions
Warfarin
Potential to alter gut flora and affect vitamin K production, which may influence INR. Monitor INR closely.
P-glycoprotein inhibitors (e.g., cyclosporine)
May significantly increase systemic exposure to rifaximin due to increased absorption.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. Symptomatic and supportive treatment is recommended in case of overdose.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs the risk. Excretion into breast milk is unknown; caution advised during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years
Availability
Pharmacies, Hospitals
Approval Status
FDA approved
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have demonstrated Rifaximin's efficacy in reducing recurrence of hepatic encephalopathy and improving symptoms of IBS-D. Ongoing research explores its role in other gastrointestinal conditions.
Lab Monitoring
- Liver function tests (for hepatic encephalopathy patients)
- INR if co-administered with warfarin
Doctor Notes
- Emphasize patient compliance with full course for optimal results.
- Monitor for signs of C. difficile infection if diarrhea worsens or persists.
- Consider potential P-gp interactions when prescribing concomitant medications.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if symptoms improve.
- Do not use if you have bloody diarrhea or fever.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
May cause dizziness or fatigue. Avoid driving or operating machinery if you experience these symptoms.
Lifestyle Advice
- Maintain adequate hydration, especially when suffering from diarrhea.
- Follow dietary recommendations provided by your doctor for hepatic encephalopathy or IBS-D.
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