Herpigel
Generic Name
Acyclovir
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Description
Overview of the medicine
Herpigel contains Acyclovir, an antiviral agent, used for the treatment of cold sores (herpes simplex labialis) and genital herpes.
Uses & Indications
Dosage
Adults
Apply to the affected area 5 times daily for 4 days. If symptoms persist, treatment may be continued for up to 10 days.
Elderly
No specific dosage adjustment required.
Renal_impairment
No specific dosage adjustment required for topical use.
How to Take
Apply a thin layer of cream to cover the affected area and the immediate surrounding healthy skin. Wash hands before and after application. Avoid touching eyes after application. Do not apply inside the mouth or nose.
Mechanism of Action
Acyclovir is a synthetic nucleoside analog that inhibits replication of herpes simplex viruses. It is phosphorylated intracellularly to its active triphosphate form, which then selectively inhibits viral DNA polymerase and incorporates into viral DNA, leading to chain termination.
Pharmacokinetics
Onset
Symptomatic relief typically within 2-3 days, complete healing within 4-10 days.
Excretion
Minimal systemic excretion following topical application.
Half life
Not relevant for topical application due to minimal systemic absorption.
Absorption
Minimal systemic absorption following topical application.
Metabolism
Minimal systemic metabolism following topical application.
Side Effects
Contraindications
- Hypersensitivity to Acyclovir, Valacyclovir, or any component of the formulation.
Drug Interactions
None reported
Minimal systemic absorption, so significant drug interactions are unlikely with topical use.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose is highly unlikely with topical administration. In case of accidental ingestion, seek medical advice.
Pregnancy & Lactation
Consult a doctor before use. Topical Acyclovir is generally considered safe during pregnancy and lactation due to minimal systemic absorption, but use only if clearly needed.
Side Effects
Contraindications
- Hypersensitivity to Acyclovir, Valacyclovir, or any component of the formulation.
Drug Interactions
None reported
Minimal systemic absorption, so significant drug interactions are unlikely with topical use.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose is highly unlikely with topical administration. In case of accidental ingestion, seek medical advice.
Pregnancy & Lactation
Consult a doctor before use. Topical Acyclovir is generally considered safe during pregnancy and lactation due to minimal systemic absorption, but use only if clearly needed.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months (check specific packaging for exact expiry date)
Availability
Available in pharmacies nationwide
Approval Status
Approved (generic)
Patent Status
Patent expired
WHO Essential Medicine
YesClinical Trials
Acyclovir has been extensively studied in numerous clinical trials demonstrating its efficacy and safety for the treatment of herpes simplex virus infections. Generic formulations are bioequivalent to the reference product.
Lab Monitoring
- No specific lab monitoring is required for topical Acyclovir.
Doctor Notes
- Emphasize early initiation of therapy at the first sign of recurrence.
- Advise patients on hygiene practices to prevent transmission.
- Counsel on realistic expectations for treatment outcomes (faster healing, but not a cure).
Patient Guidelines
- Start treatment as soon as symptoms (tingling, itching, redness) appear.
- Wash hands thoroughly before and after applying the cream.
- Avoid touching the affected area unnecessarily to prevent spreading the virus.
- Do not share towels, utensils, or lip balm to prevent spreading.
Missed Dose Advice
If a dose is missed, apply it as soon as you remember. Then continue with your regular dosing schedule. Do not apply a double dose to make up for a missed one.
Driving Precautions
Herpigel has no known effect on the ability to drive or operate machinery.
Lifestyle Advice
- Avoid triggers for cold sores such as stress, sunlight, and fever.
- Maintain good hygiene to prevent secondary infections.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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