Hexigard
Generic Name
Chlorhexidine Gluconate
Manufacturer
ACI Limited
Country
Bangladesh
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Description
Overview of the medicine
Hexigard is a brand of Chlorhexidine Gluconate, an antiseptic and disinfectant agent used primarily in oral hygiene products like mouthwashes to reduce plaque and prevent gingivitis. It's also used topically for skin disinfection.
Uses & Indications
Dosage
Adults
Rinse with 10-15 mL of 0.2% mouthwash for 30-60 seconds, twice daily after brushing teeth. Do not swallow.
Elderly
No specific dose adjustment required.
Renal_impairment
No dose adjustment required due to minimal systemic absorption.
How to Take
For oral rinse: use after brushing teeth, do not dilute, swish for 30-60 seconds then spit out. Do not eat or drink for 30 minutes after use. For topical use: apply to affected area.
Mechanism of Action
Chlorhexidine acts by disrupting the bacterial cell membrane and precipitating intracellular contents, leading to bacterial cell death. It has a broad spectrum of activity against gram-positive and gram-negative bacteria, yeasts, and some viruses.
Pharmacokinetics
Onset
Antimicrobial effect begins rapidly upon application, plaque reduction effects seen within days.
Excretion
Mainly excreted via feces when ingested, unabsorbed portion.
Half life
Not applicable for systemic half-life due to minimal absorption. Oral retention lasts several hours.
Absorption
Minimally absorbed systemically when used orally or topically.
Metabolism
Not significantly metabolized systemically due to poor absorption.
Side Effects
Contraindications
- Hypersensitivity to chlorhexidine or any components of the formulation.
- Not for use in the eyes, ears, or nervous tissue.
Drug Interactions
Sodium Lauryl Sulfate (SLS) (in toothpaste)
SLS can inactivate chlorhexidine; rinse mouth thoroughly after using SLS toothpaste before using chlorhexidine mouthwash.
Storage
Store below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Systemic overdose is unlikely with oral rinse due to minimal absorption. If large amounts are ingested, gastrointestinal upset may occur. Symptomatic treatment.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation due to minimal systemic absorption, but consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to chlorhexidine or any components of the formulation.
- Not for use in the eyes, ears, or nervous tissue.
Drug Interactions
Sodium Lauryl Sulfate (SLS) (in toothpaste)
SLS can inactivate chlorhexidine; rinse mouth thoroughly after using SLS toothpaste before using chlorhexidine mouthwash.
Storage
Store below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Systemic overdose is unlikely with oral rinse due to minimal absorption. If large amounts are ingested, gastrointestinal upset may occur. Symptomatic treatment.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation due to minimal systemic absorption, but consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, Superstores
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensively studied for its efficacy in reducing plaque and gingivitis. Ongoing research for new applications.
Lab Monitoring
- No specific lab monitoring is typically required.
Doctor Notes
- Advise patients on proper use to avoid staining and minimize interaction with SLS toothpastes.
- Be aware of rare but severe hypersensitivity reactions.
Patient Guidelines
- Do not swallow the mouthwash.
- Do not rinse mouth immediately after brushing with conventional toothpaste.
- Report any severe allergic reactions or persistent side effects to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. Do not double the dose.
Driving Precautions
Does not affect ability to drive or operate machinery.
Lifestyle Advice
- Maintain good oral hygiene practices (brushing, flossing).
- Regular dental check-ups are important.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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