Heximax
Generic Name
Hexifenadine Hydrochloride
Manufacturer
Max Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| heximax 2 mg tablet | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Heximax 2 mg tablet contains Hexifenadine Hydrochloride, a new generation non-sedating antihistamine used for the treatment of various allergic conditions such as allergic rhinitis and chronic idiopathic urticaria.
Uses & Indications
Dosage
Adults
The usual recommended dose for adults and adolescents 12 years and older is 2 mg once daily.
Elderly
No dose adjustment is typically required for elderly patients with normal renal function.
Renal_impairment
For patients with severe renal impairment (creatinine clearance <30 mL/min), a reduced dose of 1 mg once daily is recommended.
How to Take
Heximax 2 mg tablet should be taken orally, with or without food. It is recommended to take the tablet at approximately the same time each day.
Mechanism of Action
Hexifenadine Hydrochloride selectively blocks peripheral H1 histamine receptors, thereby preventing histamine from binding to these receptors and reducing the symptoms of allergic reactions such as sneezing, itching, and rhinorrhea.
Pharmacokinetics
Onset
Onset of action typically occurs within 30 to 60 minutes after administration.
Excretion
Excreted primarily through both urine and feces, with a significant portion as unchanged drug in feces.
Half life
The elimination half-life is approximately 10 to 15 hours.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations achieved within 1 to 2 hours.
Metabolism
Primarily metabolized in the liver to inactive metabolites, with minimal first-pass effect.
Side Effects
Contraindications
- Known hypersensitivity to Hexifenadine Hydrochloride or any components of the tablet.
- Patients with severe hepatic impairment.
Drug Interactions
Erythromycin
May increase plasma concentrations of Hexifenadine Hydrochloride, potentially leading to increased risk of adverse effects.
Ketoconazole
Concomitant use may increase plasma concentrations of Hexifenadine Hydrochloride.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. Gastric lavage may be considered. Hemodialysis is not expected to be effective. Closely monitor vital signs and manage symptoms as appropriate.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Caution should be exercised when Heximax is administered to a nursing mother as it is unknown whether Hexifenadine Hydrochloride is excreted in human milk.
Side Effects
Contraindications
- Known hypersensitivity to Hexifenadine Hydrochloride or any components of the tablet.
- Patients with severe hepatic impairment.
Drug Interactions
Erythromycin
May increase plasma concentrations of Hexifenadine Hydrochloride, potentially leading to increased risk of adverse effects.
Ketoconazole
Concomitant use may increase plasma concentrations of Hexifenadine Hydrochloride.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. Gastric lavage may be considered. Hemodialysis is not expected to be effective. Closely monitor vital signs and manage symptoms as appropriate.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Caution should be exercised when Heximax is administered to a nursing mother as it is unknown whether Hexifenadine Hydrochloride is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Available in pharmacies and hospitals nationwide
Approval Status
Approved by DGDA
Patent Status
Patented
Clinical Trials
Post-marketing surveillance and Phase IV clinical trials are ongoing to further evaluate the long-term efficacy and safety profile of Heximax.
Lab Monitoring
- No routine specific lab monitoring is required for Heximax 2 mg tablet. Liver function tests may be considered in patients with pre-existing hepatic impairment or during prolonged therapy.
Doctor Notes
- Advise patients to report any unusual side effects promptly.
- Consider renal function before prescribing, especially in elderly patients.
- Caution against concomitant use with strong CYP3A4 inhibitors.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Inform your doctor if your symptoms do not improve or worsen.
- Avoid alcohol while taking this medicine as it may increase drowsiness.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Heximax 2 mg tablet may cause mild drowsiness in some individuals. Patients should be cautioned about operating hazardous machinery or driving until they know how the drug affects them.
Lifestyle Advice
- Identify and avoid known allergens that trigger your symptoms.
- Maintain good hydration.
- Consider using saline nasal sprays for nasal congestion.
- Avoid smoking and exposure to secondhand smoke.
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