Heximax
Generic Name
heximax-5-mg-tablet
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| heximax 5 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Heximax 5 mg tablet contains Cetirizine Hydrochloride, a second-generation H1 receptor antagonist used for the relief of symptoms associated with perennial and seasonal allergic rhinitis, and chronic idiopathic urticaria.
Uses & Indications
Dosage
Adults
Usually 5 mg to 10 mg once daily, depending on severity of symptoms. Most common adult dose is 5 mg or 10 mg once daily.
Elderly
Typically 5 mg once daily. Dosage adjustment may be required in elderly patients with impaired renal function.
Renal_impairment
Dosage should be reduced to 5 mg once daily for patients with moderate renal impairment (creatinine clearance 31-60 mL/min). 5 mg every other day for severe renal impairment (creatinine clearance 11-30 mL/min). Contraindicated in end-stage renal disease (creatinine clearance <10 mL/min).
How to Take
Oral administration. May be taken with or without food.
Mechanism of Action
Cetirizine is a potent and highly selective H1-receptor antagonist. It works by blocking histamine, a natural substance that the body produces during an allergic reaction, thereby reducing allergy symptoms like itching, sneezing, and runny nose.
Pharmacokinetics
Onset
Within 20-60 minutes
Excretion
Primarily excreted unchanged in the urine (about 60% of the dose within 24 hours). A small amount is excreted in feces.
Half life
Approximately 8-11 hours (adults)
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are achieved within 1 hour.
Metabolism
About 10% of the dose is metabolized via O-dealkylation to a pharmacologically inactive metabolite.
Side Effects
Contraindications
- Hypersensitivity to cetirizine, hydroxyzine, or any piperazine derivatives.
- Severe renal impairment (creatinine clearance <10 mL/min).
Drug Interactions
Alcohol
Concurrent use with alcohol or other CNS depressants may lead to additive central nervous system depression, potentially impairing mental alertness and causing drowsiness.
Ritonavir
Ritonavir may increase plasma levels of cetirizine. Exercise caution.
Theophylline
A small decrease in cetirizine clearance was observed with co-administration of theophylline, but dosage adjustment is usually not necessary.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, sedation, tachycardia, tremor, and urinary retention. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered soon after ingestion.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Cetirizine is excreted in breast milk; therefore, caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to cetirizine, hydroxyzine, or any piperazine derivatives.
- Severe renal impairment (creatinine clearance <10 mL/min).
Drug Interactions
Alcohol
Concurrent use with alcohol or other CNS depressants may lead to additive central nervous system depression, potentially impairing mental alertness and causing drowsiness.
Ritonavir
Ritonavir may increase plasma levels of cetirizine. Exercise caution.
Theophylline
A small decrease in cetirizine clearance was observed with co-administration of theophylline, but dosage adjustment is usually not necessary.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, sedation, tachycardia, tremor, and urinary retention. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered soon after ingestion.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Cetirizine is excreted in breast milk; therefore, caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated cetirizine's efficacy and safety in treating various allergic conditions.
Lab Monitoring
- No routine lab monitoring is generally required.
- Consider renal function tests in patients with kidney impairment.
Doctor Notes
- Advise patients on potential for drowsiness and caution regarding driving/operating machinery.
- Consider renal dose adjustment in elderly and renally impaired patients.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid driving or operating heavy machinery if drowsiness occurs.
- Consult a doctor if symptoms do not improve within a few days or worsen.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause drowsiness or dizziness. Patients should be warned about engaging in activities requiring mental alertness, such as driving or operating machinery, until they know how Heximax affects them.
Lifestyle Advice
- Identify and avoid allergens if possible.
- Stay hydrated by drinking plenty of fluids.
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