Hipre
Generic Name
Escitalopram 10 mg
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| hipre 10 mg tablet | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
Hipre 10 mg Tablet contains Escitalopram, which is an antidepressant belonging to the Selective Serotonin Reuptake Inhibitor (SSRI) class. It is primarily used to treat various mental health conditions, including major depressive disorder and generalized anxiety disorder.
Uses & Indications
Dosage
Adults
Initial dose: 10 mg once daily. May be increased to 20 mg once daily after at least one week, based on clinical response. Max dose: 20 mg/day.
Elderly
Initial dose: 5 mg once daily. May be increased to 10 mg once daily after at least one week. Max dose: 10 mg/day.
Renal_impairment
No dosage adjustment needed for mild to moderate renal impairment. Use with caution in severe impairment.
How to Take
Take orally once daily, with or without food. Swallow the tablet whole with water.
Mechanism of Action
Escitalopram selectively inhibits the reuptake of serotonin (5-HT) in the central nervous system, leading to an potentiation of serotonergic activity in the brain. This results in an antidepressant effect and helps in managing anxiety disorders.
Pharmacokinetics
Onset
Initial antidepressant effects may be observed within 2-4 weeks; full effects may take longer.
Excretion
Mainly through hepatic metabolism, followed by renal and fecal excretion. Approximately 8% of the dose is excreted unchanged in urine.
Half life
Approximately 27-32 hours (single dose), extending to 50 hours with multiple doses.
Absorption
Well absorbed orally, bioavailability is about 80%. Absorption is not affected by food.
Metabolism
Extensively metabolized in the liver by CYP2C19, CYP3A4, and CYP2D6 to its primary metabolites, S-desmethylcitalopram and S-didesmethylcitalopram.
Side Effects
Contraindications
- Hypersensitivity to escitalopram or any component of the formulation.
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing MAOI therapy due to risk of serotonin syndrome.
- Concomitant use with pimozide (due to QT prolongation risk).
Drug Interactions
MAOIs
Risk of serotonin syndrome (hyperthermia, rigidity, myoclonus, autonomic instability).
Alcohol
Enhances CNS depressive effects; avoid concomitant use.
Pimozide
Increased pimozide levels and QT prolongation.
Triptans
Increased risk of serotonin syndrome.
Warfarin
Increased risk of bleeding due to potential changes in INR.
NSAIDs/Aspirin
Increased risk of gastrointestinal bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include dizziness, tremor, agitation, convulsion, somnolence, coma, nausea, vomiting, tachycardia, hypotension, and ECG changes (e.g., QT prolongation). Treatment is supportive and symptomatic; maintain airway, monitor cardiac and vital signs. Activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Escitalopram is excreted in human milk; advise caution when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to escitalopram or any component of the formulation.
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing MAOI therapy due to risk of serotonin syndrome.
- Concomitant use with pimozide (due to QT prolongation risk).
Drug Interactions
MAOIs
Risk of serotonin syndrome (hyperthermia, rigidity, myoclonus, autonomic instability).
Alcohol
Enhances CNS depressive effects; avoid concomitant use.
Pimozide
Increased pimozide levels and QT prolongation.
Triptans
Increased risk of serotonin syndrome.
Warfarin
Increased risk of bleeding due to potential changes in INR.
NSAIDs/Aspirin
Increased risk of gastrointestinal bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include dizziness, tremor, agitation, convulsion, somnolence, coma, nausea, vomiting, tachycardia, hypotension, and ECG changes (e.g., QT prolongation). Treatment is supportive and symptomatic; maintain airway, monitor cardiac and vital signs. Activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Escitalopram is excreted in human milk; advise caution when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
Approved by FDA and DGDA
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated efficacy and safety in the treatment of MDD, GAD, PD, SAD, and OCD. Ongoing post-marketing surveillance.
Lab Monitoring
- Monitor for hyponatremia, especially in elderly patients or those taking diuretics. Periodic ECG may be considered for patients with cardiac risk factors.
Doctor Notes
- Counsel patients on delayed onset of action and the importance of continued therapy.
- Monitor for worsening depression and suicidality, especially at treatment initiation or dose changes.
- Advise patients about potential sexual side effects and discuss management strategies.
Patient Guidelines
- Take Hipre 10 mg Tablet exactly as prescribed by your doctor.
- Do not stop taking the medicine suddenly, as it may lead to withdrawal symptoms. Consult your doctor for gradual dosage reduction.
- Avoid alcohol while taking this medicine.
- Report any unusual mood changes, agitation, or suicidal thoughts to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose.
Driving Precautions
Hipre may cause drowsiness, dizziness, or blurred vision. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Engage in regular physical activity.
- Maintain a balanced diet and adequate sleep.
- Practice stress-reduction techniques like meditation or yoga.
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