Hipre

Take orally with or without food, usually once daily.

Amlodipine blocks L-type calcium channels in the smooth muscle cells of blood vessels and the heart. This leads to vasodilation (widening of blood vessels), decreased peripheral vascular resistance, and reduced cardiac afterload, resulting in lower blood pressure. In angina, it increases myocardial oxygen supply by dilating coronary arteries.

• Hypersensitivity to Amlodipine or other dihydropyridine derivatives
• Severe hypotension
• Cardiogenic shock
• Obstruction of the outflow tract of the left ventricle (e.g., high grade aortic stenosis)
• Hemodynamically unstable heart failure after acute myocardial infarction

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Symptoms: Profound and prolonged systemic hypotension with possible reflex tachycardia. Management: Symptomatic and supportive. If recent ingestion, gastric lavage. Administer activated charcoal. Clinically significant hypotension requires active cardiovascular support including monitoring of cardiac and respiratory function, elevation of extremities, and administration of fluids. Vasopressors (e.g., norepinephrine) may be helpful. Intravenous calcium gluconate may reverse the effects of calcium channel blockade.

Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Small amounts of amlodipine are excreted in human milk; caution should be exercised when amlodipine is administered to a nursing woman.