Hitflam
Generic Name
Diclofenac Diethylamine 1.16% w/w (equivalent to Diclofenac Sodium 1% w/w)
Manufacturer
The ACME Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| hitflam 1 w gel | ৳ 12.95 | N/A |
Description
Overview of the medicine
Hitflam 1% w/w Gel is a non-steroidal anti-inflammatory drug (NSAID) used for the topical treatment of pain and inflammation associated with various musculoskeletal conditions.
Uses & Indications
Dosage
Adults
Apply a small amount (2-4g, size of a cherry or walnut depending on the affected area) to the affected area 3-4 times daily and rub gently into the skin.
Elderly
No specific dose adjustment required; use as per adult dosage.
Renal_impairment
No specific dose adjustment required as systemic absorption is minimal.
How to Take
For external use only. Apply thinly to the affected skin area and rub in gently. Do not apply to open wounds, infected skin, or mucous membranes.
Mechanism of Action
Inhibits cyclooxygenase (COX-1 and COX-2) enzymes, leading to a reduction in prostaglandin synthesis, thereby reducing pain and inflammation.
Pharmacokinetics
Onset
Pain relief typically within 30-60 minutes.
Excretion
Mainly via urine (metabolites) and bile.
Half life
Systemic plasma half-life is about 1-2 hours; local therapeutic effects persist longer.
Absorption
Limited systemic absorption; high local tissue concentration achieved.
Metabolism
Primarily hepatic, mainly by CYP2C9.
Side Effects
Contraindications
- Hypersensitivity to diclofenac, aspirin, or other NSAIDs.
- Patients with a history of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
- Application to broken skin, open wounds, infected skin, or eczema.
Drug Interactions
Methotrexate
Possible increase in methotrexate levels, though clinically significant interaction is unlikely with topical use.
Oral anticoagulants (e.g., warfarin)
Increased risk of bleeding, though systemic absorption is minimal.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Overdose is unlikely with topical application due to minimal systemic absorption. If excessive amounts are applied, wipe off the excess and wash the area. In case of accidental ingestion, seek medical attention immediately.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy. Use with caution in the first and second trimesters and during lactation, only if the potential benefit justifies the potential risk to the fetus/infant. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to diclofenac, aspirin, or other NSAIDs.
- Patients with a history of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
- Application to broken skin, open wounds, infected skin, or eczema.
Drug Interactions
Methotrexate
Possible increase in methotrexate levels, though clinically significant interaction is unlikely with topical use.
Oral anticoagulants (e.g., warfarin)
Increased risk of bleeding, though systemic absorption is minimal.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Overdose is unlikely with topical application due to minimal systemic absorption. If excessive amounts are applied, wipe off the excess and wash the area. In case of accidental ingestion, seek medical attention immediately.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy. Use with caution in the first and second trimesters and during lactation, only if the potential benefit justifies the potential risk to the fetus/infant. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies and drugstores
Approval Status
Approved
Patent Status
Expired
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of topical diclofenac for musculoskeletal pain and inflammation.
Lab Monitoring
- No specific lab monitoring required for topical diclofenac due to minimal systemic absorption.
Doctor Notes
- Advise patients on proper application technique and duration of use.
- Educate on signs of local skin reactions and when to discontinue use.
- Consider systemic NSAID warnings for patients with pre-existing cardiovascular or gastrointestinal conditions if there is concern about extensive systemic absorption.
Patient Guidelines
- Apply only to intact, healthy skin. Do not apply to open wounds or damaged skin.
- Wash hands thoroughly after application to avoid accidental transfer to eyes or other sensitive areas.
- Do not cover the treated area with occlusive bandages or dressings unless advised by a doctor.
Missed Dose Advice
Apply the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not apply extra gel to make up for a missed dose.
Driving Precautions
Hitflam 1% w/w Gel is not known to affect the ability to drive or operate machinery.
Lifestyle Advice
- Combine with rest and appropriate physical therapy for musculoskeletal pain.
- Avoid prolonged exposure to sunlight or artificial UV light on the treated area to minimize photosensitivity risk.
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Global Brand Names
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