Humphry
Generic Name
Amoflaxacin
Manufacturer
PharmaCorp Global
Country
USA
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| humphry 400 mg tablet | ৳ 8.02 | ৳ 80.20 |
Description
Overview of the medicine
Humphry 400 mg Tablet is a broad-spectrum antibiotic used to treat various bacterial infections.
Uses & Indications
Dosage
Adults
Typically 400 mg once daily for 7-14 days, depending on the infection type and severity.
Elderly
No specific dosage adjustment required based on age alone, but consider renal function.
Renal_impairment
Dosage reduction is necessary for patients with creatinine clearance < 30 mL/min.
How to Take
Administer orally with or without food. Do not take with dairy products or calcium-fortified juices.
Mechanism of Action
It works by inhibiting bacterial DNA gyrase and topoisomerase IV enzymes, which are essential for bacterial DNA replication, transcription, repair, and recombination, thereby leading to bacterial cell death.
Pharmacokinetics
Onset
Effective concentrations typically reached within 1-2 hours.
Excretion
Primarily excreted unchanged in the urine, with some fecal excretion.
Half life
Approximately 8-12 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract after oral administration.
Metabolism
Partially metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to Amoflaxacin or other fluoroquinolone antibiotics.
- History of quinolone-associated tendinitis or tendon rupture.
Drug Interactions
Warfarin
May enhance the anticoagulant effects of warfarin, increasing the risk of bleeding.
Corticosteroids
Concomitant use may increase the risk of tendon rupture.
Antacids containing aluminum or magnesium
May decrease absorption of Amoflaxacin; take Amoflaxacin 2 hours before or 6 hours after antacids.
Storage
Store below 25°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Not recommended during pregnancy or lactation due to potential risks to the fetus/infant, unless clearly necessary and prescribed by a doctor.
Side Effects
Contraindications
- Hypersensitivity to Amoflaxacin or other fluoroquinolone antibiotics.
- History of quinolone-associated tendinitis or tendon rupture.
Drug Interactions
Warfarin
May enhance the anticoagulant effects of warfarin, increasing the risk of bleeding.
Corticosteroids
Concomitant use may increase the risk of tendon rupture.
Antacids containing aluminum or magnesium
May decrease absorption of Amoflaxacin; take Amoflaxacin 2 hours before or 6 hours after antacids.
Storage
Store below 25°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Not recommended during pregnancy or lactation due to potential risks to the fetus/infant, unless clearly necessary and prescribed by a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies and hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Patent Protected
Clinical Trials
Extensive Phase III clinical trials have been conducted, demonstrating its efficacy and safety profile in various bacterial infections.
Lab Monitoring
- Renal function tests
- Liver function tests
- ECG monitoring (if risk factors for QT prolongation exist)
Doctor Notes
- Confirm bacterial susceptibility through culture and sensitivity testing prior to initiating therapy.
- Educate patients on potential serious adverse effects, especially regarding tendinopathy and neuropathy, and to discontinue immediately if symptoms occur.
- Ensure complete adherence to the prescribed treatment duration to prevent resistance development.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if you feel better.
- Do not share this medication with others.
- Report any unusual or severe side effects to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular schedule. Do not double the dose.
Driving Precautions
This medication may cause dizziness or lightheadedness, which could impair your ability to drive or operate machinery. Exercise caution.
Lifestyle Advice
- Stay well-hydrated by drinking plenty of fluids.
- Avoid excessive exposure to sunlight or artificial UV light while taking this medication.
- Avoid strenuous physical activity if you experience tendon pain.
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