Humphry
Generic Name
Humphry 740 mg Tablet
Manufacturer
Acme Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| humphry 740 mg tablet | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Humphry 740 mg Tablet is a broad-spectrum antibiotic used to treat a wide range of bacterial infections. It works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
One 740 mg tablet once daily for 3-7 days, depending on infection severity.
Elderly
No specific dose adjustment is usually required, but monitor renal function.
Renal_impairment
Mild to moderate impairment: No adjustment. Severe impairment: Use with caution, consider dose reduction.
How to Take
Take the tablet whole with a glass of water, with or without food. Do not crush or chew.
Mechanism of Action
Humphry 740 mg Tablet inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby interfering with the translocation of peptides. This leads to a bacteriostatic effect, preventing the growth and multiplication of susceptible bacteria.
Pharmacokinetics
Onset
Peak plasma concentrations reached within 2-3 hours.
Excretion
Mainly through bile and feces, a small portion via urine.
Half life
Approximately 12-15 hours, allowing for once-daily dosing.
Absorption
Well absorbed orally, bioavailability is around 60-70%. Food may slightly decrease absorption.
Metabolism
Primarily hepatic, undergoes partial metabolism via CYP3A4 enzymes.
Side Effects
Contraindications
- Known hypersensitivity to Humphry or any macrolide antibiotic
- Severe hepatic impairment
- History of cholestatic jaundice/hepatic dysfunction associated with prior use of macrolides
Drug Interactions
Digoxin
May increase digoxin levels; monitor digoxin concentration.
Warfarin
May increase anticoagulant effect; monitor INR.
Cyclosporine
May increase cyclosporine levels; monitor cyclosporine concentration.
Antacids (aluminum and magnesium-containing)
May reduce absorption; separate administration by 2 hours.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage and symptomatic supportive treatment are recommended. Hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk; caution advised during lactation.
Side Effects
Contraindications
- Known hypersensitivity to Humphry or any macrolide antibiotic
- Severe hepatic impairment
- History of cholestatic jaundice/hepatic dysfunction associated with prior use of macrolides
Drug Interactions
Digoxin
May increase digoxin levels; monitor digoxin concentration.
Warfarin
May increase anticoagulant effect; monitor INR.
Cyclosporine
May increase cyclosporine levels; monitor cyclosporine concentration.
Antacids (aluminum and magnesium-containing)
May reduce absorption; separate administration by 2 hours.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage and symptomatic supportive treatment are recommended. Hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk; caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Underwent Phase I, II, and III clinical trials demonstrating efficacy and safety. Post-marketing surveillance continues.
Lab Monitoring
- Liver function tests (for prolonged therapy or hepatic impairment)
- Renal function tests (for prolonged therapy or renal impairment)
Doctor Notes
- Prescribe based on sensitivity testing results if possible.
- Emphasize patient adherence to the full course of treatment.
- Monitor for signs of C. difficile infection.
Patient Guidelines
- Complete the entire course of medication, even if symptoms improve.
- Do not share this medicine with others.
- Inform your doctor about all other medications, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose.
Driving Precautions
May cause dizziness in some individuals. Exercise caution when driving or operating machinery.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Ensure adequate rest to support recovery.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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