Hyginol
Generic Name
Povidone-Iodine 0.1% & Hydrocortisone 0.05% Cream
Manufacturer
MediCare Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| hyginol 01 05 cream | ৳ 22.00 | N/A |
Description
Overview of the medicine
Hyginol-01-05-Cream is a topical preparation combining an antiseptic (Povidone-Iodine 0.1%) and a mild corticosteroid (Hydrocortisone 0.05%) for the treatment of various skin conditions characterized by inflammation and potential infection.
Uses & Indications
Dosage
Adults
Apply a thin layer to the affected area 2-3 times daily, or as directed by physician.
Elderly
No specific dosage adjustment required, use with caution.
Renal_impairment
No specific dosage adjustment required for topical use, but caution advised with extensive use on broken skin.
How to Take
For external use only. Wash hands before and after application. Apply a thin film to the clean, dry affected skin area and rub gently. Do not apply to eyes or mucous membranes.
Mechanism of Action
Povidone-Iodine acts as a broad-spectrum antiseptic, releasing iodine slowly to kill bacteria, viruses, fungi, and protozoa. Hydrocortisone is a corticosteroid that reduces inflammation, itching, and redness by suppressing the immune response in the skin.
Pharmacokinetics
Onset
Within minutes for antiseptic action, hours for anti-inflammatory effects.
Excretion
Mainly through kidneys for systemically absorbed components.
Half life
Not precisely defined for topical application with minimal systemic absorption; systemic half-life of hydrocortisone is approximately 1.5-2 hours.
Absorption
Minimal systemic absorption through intact skin. Absorption may increase with broken skin, occlusion, or application to large areas. Iodine from Povidone-Iodine can be absorbed. Hydrocortisone also has some systemic absorption.
Metabolism
Hydrocortisone is primarily metabolized in the liver to inactive metabolites. Povidone-Iodine is largely not metabolized, but absorbed iodine is handled by the body.
Side Effects
Contraindications
- Hypersensitivity to Povidone-Iodine, Hydrocortisone, or any excipients
- Thyroid disorders (due to iodine absorption)
- Extensive, deep burns
- Perforated eardrum (if applied to ear area)
Drug Interactions
Lithium
Systemic absorption of iodine may interfere with lithium therapy, potentially causing hypothyroidism.
Other topical preparations
Avoid concurrent use unless directed by a physician, as it may alter absorption or efficacy.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Systemic overdose from topical application is unlikely but possible with extensive use on large areas of broken skin. Symptoms might include thyroid dysfunction (from iodine) or Cushing's syndrome (from hydrocortisone). Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy and lactation only if clearly needed and advised by a physician, as systemic absorption of iodine and corticosteroids can occur.
Side Effects
Contraindications
- Hypersensitivity to Povidone-Iodine, Hydrocortisone, or any excipients
- Thyroid disorders (due to iodine absorption)
- Extensive, deep burns
- Perforated eardrum (if applied to ear area)
Drug Interactions
Lithium
Systemic absorption of iodine may interfere with lithium therapy, potentially causing hypothyroidism.
Other topical preparations
Avoid concurrent use unless directed by a physician, as it may alter absorption or efficacy.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Systemic overdose from topical application is unlikely but possible with extensive use on large areas of broken skin. Symptoms might include thyroid dysfunction (from iodine) or Cushing's syndrome (from hydrocortisone). Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy and lactation only if clearly needed and advised by a physician, as systemic absorption of iodine and corticosteroids can occur.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Clinical studies have demonstrated the efficacy and safety of the combination of Povidone-Iodine and Hydrocortisone in treating mild to moderate infected dermatoses.
Lab Monitoring
- Thyroid function tests (for extensive use or long duration due to iodine absorption)
- Adrenal function tests (for prolonged, extensive use of corticosteroid)
Doctor Notes
- Advise patients on appropriate application technique and duration of treatment.
- Monitor for signs of secondary infection or worsening of skin condition.
- Educate on potential for systemic absorption with extensive or prolonged use.
Patient Guidelines
- Do not use for more than 7 days without consulting a doctor.
- Avoid contact with eyes, nose, mouth, and other mucous membranes.
- Do not cover the treated area with bandages or airtight dressings unless directed by a doctor.
- Stop use and consult a doctor if irritation or infection worsens.
Missed Dose Advice
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not apply extra cream to make up for a missed dose.
Driving Precautions
Not applicable for a topical cream, as it does not affect ability to drive or operate machinery.
Lifestyle Advice
- Maintain good personal hygiene to prevent recurrence of infections.
- Keep the affected area clean and dry.
- Avoid sharing towels or personal items.
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