icand
Generic Name
Icand 100 mg Capsule
Manufacturer
Pioneer Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| icand 100 mg capsule | ৳ 14.00 | ৳ 140.00 |
Description
Overview of the medicine
Icand 100 mg Capsule is an antifungal medication used to treat various fungal infections of the skin, nails, and internal organs. It works by stopping the growth of fungi.
Uses & Indications
Dosage
Adults
Varies by indication: e.g., Onychomycosis: 200 mg once daily for 3 months or pulse therapy (200 mg twice daily for 1 week, followed by 3 weeks off, for 2-3 cycles). Systemic candidiasis: 100-200 mg once or twice daily.
Elderly
No specific dose adjustment is generally required, but caution should be exercised due to potential age-related organ function decline.
Renal_impairment
Use with caution; dose adjustment may be necessary. Plasma concentrations may be higher in patients with renal impairment.
How to Take
Take the capsule orally immediately after a full meal for maximal absorption. Swallow whole with water.
Mechanism of Action
Icand inhibits fungal cytochrome P450-dependent 14α-demethylation of lanosterol, which is an essential step in ergosterol biosynthesis. Ergosterol is a vital component of fungal cell membranes, and its inhibition leads to increased fungal cell membrane permeability, leakage of cellular contents, and eventually fungal cell death.
Pharmacokinetics
Onset
Therapeutic effects may take several days to weeks to appear, depending on the infection type and location.
Excretion
Excreted mainly as inactive metabolites: approximately 35% in urine and 54% in feces. Less than 0.05% is excreted unchanged in urine.
Half life
The elimination half-life is approximately 15-42 hours, with steady-state concentrations achieved within 7-14 days.
Absorption
Oral absorption is variable and significantly increased when taken with food. Bioavailability is approximately 55% and can be further enhanced by acidic conditions.
Metabolism
Extensively metabolized in the liver, primarily by the cytochrome P450 3A4 (CYP3A4) enzyme system, into various metabolites, including the active metabolite hydroxy-icand.
Side Effects
Contraindications
- Hypersensitivity to icand or any component of the formulation
- Co-administration with certain CYP3A4 substrates (e.g., cisapride, dofetilide, pimozide, quinidine, levacetylmethadol, ergot alkaloids)
- Patients with congestive heart failure or a history of congestive heart failure, unless the benefits outweigh the risks (especially for onychomycosis and other non-life-threatening indications)
Drug Interactions
Warfarin
Enhanced anticoagulant effect. Monitor INR closely and adjust warfarin dose.
Oral Midazolam/Triazolam
Increased sedation and prolonged effects. Avoid co-administration.
Proton Pump Inhibitors/Antacids
Reduce gastric acidity, impairing icand absorption. Administer at least 2 hours apart.
Statins (e.g., Simvastatin, Lovastatin)
Increased risk of myopathy/rhabdomyolysis due to elevated statin levels. Co-administration is contraindicated.
CYP3A4 Inducers (e.g., Rifampicin, Phenytoin)
May significantly decrease icand plasma levels, reducing efficacy. Avoid co-administration.
CYP3A4 Inhibitors (e.g., Ritonavir, Clarithromycin)
May significantly increase icand plasma levels, increasing risk of adverse effects. Dose adjustment may be necessary.
Storage
Store below 30°C in a dry place. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, supportive measures should be employed. Icand is not removed by hemodialysis. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C/D (depending on indication and duration). Should not be used during pregnancy unless the potential benefits outweigh the risks. Women of childbearing potential should use effective contraception during treatment and for two months after stopping. Avoid during lactation as icand is excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to icand or any component of the formulation
- Co-administration with certain CYP3A4 substrates (e.g., cisapride, dofetilide, pimozide, quinidine, levacetylmethadol, ergot alkaloids)
- Patients with congestive heart failure or a history of congestive heart failure, unless the benefits outweigh the risks (especially for onychomycosis and other non-life-threatening indications)
Drug Interactions
Warfarin
Enhanced anticoagulant effect. Monitor INR closely and adjust warfarin dose.
Oral Midazolam/Triazolam
Increased sedation and prolonged effects. Avoid co-administration.
Proton Pump Inhibitors/Antacids
Reduce gastric acidity, impairing icand absorption. Administer at least 2 hours apart.
Statins (e.g., Simvastatin, Lovastatin)
Increased risk of myopathy/rhabdomyolysis due to elevated statin levels. Co-administration is contraindicated.
CYP3A4 Inducers (e.g., Rifampicin, Phenytoin)
May significantly decrease icand plasma levels, reducing efficacy. Avoid co-administration.
CYP3A4 Inhibitors (e.g., Ritonavir, Clarithromycin)
May significantly increase icand plasma levels, increasing risk of adverse effects. Dose adjustment may be necessary.
Storage
Store below 30°C in a dry place. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, supportive measures should be employed. Icand is not removed by hemodialysis. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C/D (depending on indication and duration). Should not be used during pregnancy unless the potential benefits outweigh the risks. Women of childbearing potential should use effective contraception during treatment and for two months after stopping. Avoid during lactation as icand is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA, Bangladesh
Patent Status
Generic available
Clinical Trials
Clinical trials for systemic antifungals, including icand's active ingredient, have demonstrated efficacy and safety across various fungal infections, with ongoing post-marketing surveillance for rare adverse events.
Lab Monitoring
- Liver function tests (LFTs) should be performed before treatment and periodically during prolonged therapy, especially in patients with pre-existing hepatic impairment.
- Serum potassium levels should be monitored in patients at risk of hypokalemia.
Doctor Notes
- Emphasize the importance of taking icand with food for optimal absorption.
- Educate patients on potential drug interactions, especially with CYP3A4 substrates/inhibitors.
- Monitor liver function tests (LFTs) periodically, especially in patients on prolonged therapy or with risk factors for hepatic dysfunction.
- Advise patients to report any symptoms of heart failure (e.g., shortness of breath, edema) immediately.
Patient Guidelines
- Complete the full course of medication even if symptoms improve to prevent recurrence.
- Take the capsule with a full meal to ensure proper absorption.
- Report any unusual side effects, especially severe stomach pain, unusual tiredness, yellowing of the skin or eyes, or dark urine, to your doctor immediately.
- Avoid grapefruit juice during treatment.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Icand may cause dizziness or blurred vision. If these effects occur, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain good personal hygiene, especially for nail and skin infections.
- Avoid sharing personal items like towels, shoes, and nail clippers to prevent spreading fungal infections.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in icand Brand
Other medicines available under the same brand name
