Take orally with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water.

Imacene works by inhibiting the activity of cyclooxygenase (COX) enzymes, particularly COX-2, which are responsible for the synthesis of prostaglandins. Prostaglandins are mediators of pain, inflammation, and fever.

• •Hypersensitivity to Imacene or other NSAIDs
• •Active peptic ulcer or gastrointestinal bleeding
• •Severe renal or hepatic impairment
• •Severe heart failure
• •Third trimester of pregnancy
• •History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Symptoms of overdose may include nausea, vomiting, epigastric pain, lethargy, drowsiness, and gastrointestinal bleeding. Management involves symptomatic and supportive care. Gastric lavage or activated charcoal may be considered if ingested recently. Monitor renal and liver function.

Pregnancy Category C (D in third trimester). Avoid use in the third trimester due to potential premature closure of the fetal ductus arteriosus. Use with caution in first and second trimesters only if potential benefit justifies the potential risk to the fetus. Not recommended during lactation as Imacene may pass into breast milk.