Imacent
Generic Name
Imacene
Manufacturer
Global Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| imacent 100 mg tablet | ৳ 100.00 | ৳ 1,000.00 |
Description
Overview of the medicine
Imacent 100 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used for the relief of pain, inflammation, and fever. It is effective in treating various conditions such as osteoarthritis, rheumatoid arthritis, musculoskeletal pain, and dysmenorrhea.
Uses & Indications
Dosage
Adults
100 mg once or twice daily, or as directed by a physician. Maximum dose not to exceed 200 mg per day.
Elderly
Lower doses may be required due to increased sensitivity and potential for adverse effects. Consult a physician.
Renal_impairment
Dose adjustment may be necessary. Initiate with a lower dose and monitor renal function. Avoid in severe renal impairment.
How to Take
Take orally with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water.
Mechanism of Action
Imacene works by inhibiting the activity of cyclooxygenase (COX) enzymes, particularly COX-2, which are responsible for the synthesis of prostaglandins. Prostaglandins are mediators of pain, inflammation, and fever.
Pharmacokinetics
Onset
Pain relief usually starts within 30-60 minutes.
Excretion
Excreted mainly via the kidneys (urine), with a smaller portion excreted in feces.
Half life
Approximately 2-4 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations achieved within 1-2 hours after oral administration.
Metabolism
Primarily metabolized in the liver by cytochrome P450 enzymes.
Side Effects
Contraindications
- Hypersensitivity to Imacene or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Other NSAIDs or Aspirin
Increased risk of adverse effects, avoid concomitant use.
Diuretics and ACE inhibitors
Reduced efficacy of these medications and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric pain, lethargy, drowsiness, and gastrointestinal bleeding. Management involves symptomatic and supportive care. Gastric lavage or activated charcoal may be considered if ingested recently. Monitor renal and liver function.
Pregnancy & Lactation
Pregnancy Category C (D in third trimester). Avoid use in the third trimester due to potential premature closure of the fetal ductus arteriosus. Use with caution in first and second trimesters only if potential benefit justifies the potential risk to the fetus. Not recommended during lactation as Imacene may pass into breast milk.
Side Effects
Contraindications
- Hypersensitivity to Imacene or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Other NSAIDs or Aspirin
Increased risk of adverse effects, avoid concomitant use.
Diuretics and ACE inhibitors
Reduced efficacy of these medications and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric pain, lethargy, drowsiness, and gastrointestinal bleeding. Management involves symptomatic and supportive care. Gastric lavage or activated charcoal may be considered if ingested recently. Monitor renal and liver function.
Pregnancy & Lactation
Pregnancy Category C (D in third trimester). Avoid use in the third trimester due to potential premature closure of the fetal ductus arteriosus. Use with caution in first and second trimesters only if potential benefit justifies the potential risk to the fetus. Not recommended during lactation as Imacene may pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patented
Clinical Trials
Pre-clinical and clinical trials demonstrated efficacy in reducing pain and inflammation with a generally favorable safety profile. Further post-marketing surveillance continues.
Lab Monitoring
- Complete Blood Count (CBC) for signs of anemia or bleeding (especially with long-term use)
- Renal function tests (serum creatinine, BUN) periodically
- Liver function tests (ALT, AST) periodically
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
- Monitor for signs of GI bleeding or cardiovascular adverse events, especially in high-risk patients.
- Assess renal function periodically, particularly in elderly or renally impaired patients.
Patient Guidelines
- Do not exceed the recommended dose.
- Take with food or milk to reduce stomach upset.
- Inform your doctor about all other medications you are taking.
- Report any signs of unusual bleeding, severe stomach pain, or black stools immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
This medicine may cause dizziness or drowsiness in some individuals. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Maintain adequate hydration.
- Avoid alcohol consumption while taking this medication.
- Discuss with your doctor about regular exercise for musculoskeletal conditions.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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