Imacent
Generic Name
imacent-400-mg-tablet
Manufacturer
MediCo Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| imacent 400 mg tablet | ৳ 300.00 | ৳ 1,800.00 |
Description
Overview of the medicine
Imacent 400 mg Tablet is a broad-spectrum fluoroquinolone antibiotic used to treat a variety of bacterial infections.
Uses & Indications
Dosage
Adults
400 mg orally once daily for 7-14 days, depending on the infection severity and type.
Elderly
No specific dose adjustment is typically required unless severe renal impairment is present.
Renal_impairment
For CrCl < 30 mL/min, reduce dose to 200 mg once daily or extend dosing interval.
How to Take
Imacent 400 mg Tablet can be taken with or without food. Swallow the tablet whole with a glass of water. Do not crush or chew.
Mechanism of Action
Imacent, the active ingredient, inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination, leading to bacterial cell death.
Pharmacokinetics
Onset
Clinical effects observed within a few hours to a day, depending on the infection.
Excretion
Primarily via renal excretion (both glomerular filtration and tubular secretion) and to a lesser extent via feces.
Half life
Approximately 5-8 hours.
Absorption
Rapid and well-absorbed from the gastrointestinal tract, with peak plasma concentrations reached within 1-2 hours.
Metabolism
Limited hepatic metabolism, primarily excreted as unchanged drug.
Side Effects
Contraindications
- Hypersensitivity to Imacent or other fluoroquinolones.
- History of tendon disorders related to fluoroquinolone administration.
- Patients with epilepsy or other seizure disorders.
Drug Interactions
Warfarin
May potentiate the anticoagulant effect of warfarin, increasing the risk of bleeding. Close monitoring of INR is recommended.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Concomitant use may increase the risk of CNS stimulation and convulsive seizures.
Antacids containing aluminum or magnesium, iron supplements, sucralfate, or zinc
These agents can significantly reduce the absorption of Imacent. Administer Imacent at least 2 hours before or 4 hours after these products.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
In case of overdose, supportive measures should be initiated. Gastric lavage and activated charcoal may be considered if ingestion is recent. Monitor ECG for QT prolongation. Hemodialysis is not effective.
Pregnancy & Lactation
Imacent is generally not recommended during pregnancy or breastfeeding due to potential risks to the fetus/infant. Consult a doctor for alternatives.
Side Effects
Contraindications
- Hypersensitivity to Imacent or other fluoroquinolones.
- History of tendon disorders related to fluoroquinolone administration.
- Patients with epilepsy or other seizure disorders.
Drug Interactions
Warfarin
May potentiate the anticoagulant effect of warfarin, increasing the risk of bleeding. Close monitoring of INR is recommended.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Concomitant use may increase the risk of CNS stimulation and convulsive seizures.
Antacids containing aluminum or magnesium, iron supplements, sucralfate, or zinc
These agents can significantly reduce the absorption of Imacent. Administer Imacent at least 2 hours before or 4 hours after these products.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
In case of overdose, supportive measures should be initiated. Gastric lavage and activated charcoal may be considered if ingestion is recent. Monitor ECG for QT prolongation. Hemodialysis is not effective.
Pregnancy & Lactation
Imacent is generally not recommended during pregnancy or breastfeeding due to potential risks to the fetus/infant. Consult a doctor for alternatives.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved
Patent Status
Patent expired (generic available)
Clinical Trials
Ongoing post-marketing surveillance for rare adverse effects and long-term safety data. Initial clinical trials demonstrated efficacy in various bacterial infections.
Lab Monitoring
- Renal function tests (creatinine, BUN) in patients with renal impairment.
- Complete blood count (CBC) during prolonged therapy.
- INR monitoring for patients on warfarin.
Doctor Notes
- Counsel patients on potential severe adverse reactions, especially tendon-related issues and neurological effects.
- Adjust dosage in patients with renal impairment to avoid accumulation and toxicity.
Patient Guidelines
- Complete the full course of antibiotics as prescribed by your doctor, even if you feel better.
- Avoid excessive exposure to sunlight or artificial UV light while taking this medication.
- Report any joint pain, swelling, or unusual sensations immediately to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness or lightheadedness, affecting your ability to drive or operate machinery. Avoid such activities until you know how Imacent affects you.
Lifestyle Advice
- Stay well-hydrated by drinking plenty of fluids.
- Avoid strenuous exercise during treatment, especially if you experience any tendon discomfort.
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