Indaren-G
Generic Name
Propranolol Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| indaren g 110 mcg inhalation capsule | ৳ 70.00 | ৳ 700.00 |
Description
Overview of the medicine
Indaren-G (Propranolol Hydrochloride) is a non-selective beta-adrenergic receptor blocker used to treat various conditions including hypertension, angina pectoris, arrhythmias, essential tremor, and migraine prophylaxis.
Uses & Indications
Dosage
Adults
Hypertension: Initially 40 mg twice daily, may be increased to 80-320 mg/day in divided doses.
Elderly
Lower initial doses may be considered, and titration should be cautious.
Renal_impairment
No dose adjustment needed for mild to moderate renal impairment; monitor carefully in severe impairment.
How to Take
Take orally, preferably with or after food, at the same time each day to maintain consistent blood levels.
Mechanism of Action
Propranolol non-selectively blocks beta1 and beta2 adrenergic receptors, leading to decreased heart rate, reduced myocardial contractility, and lower blood pressure. It also inhibits renin release and has anti-arrhythmic effects.
Pharmacokinetics
Onset
1-2 hours (oral)
Excretion
Primarily excreted in the urine as metabolites, with only a small amount of unchanged drug.
Half life
3-6 hours
Absorption
Well absorbed orally, but undergoes significant first-pass metabolism. Bioavailability is about 25-50%.
Metabolism
Extensively metabolized in the liver by aromatic hydroxylation, N-dealkylation, and glucuronidation.
Side Effects
Contraindications
- •Bronchial asthma or bronchospasm
- •Cardiogenic shock
- •Sinus bradycardia (<50 beats/min)
- •Second or third-degree atrioventricular block
- •Sick sinus syndrome
- •Severe hypotension
- •Uncontrolled heart failure
Drug Interactions
NSAIDs (e.g., Ibuprofen)
May reduce antihypertensive effect.
Insulin/Oral Antidiabetics
May mask symptoms of hypoglycemia and alter glucose levels.
Antiarrhythmics (e.g., Amiodarone)
Increased risk of cardiac depression.
Calcium Channel Blockers (e.g., Verapamil, Diltiazem)
Increased risk of bradycardia and hypotension.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms include severe bradycardia, hypotension, heart failure, and bronchospasm. Treatment is symptomatic and supportive, including atropine for bradycardia and glucagon for refractory hypotension.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk. Excreted in breast milk; consult doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Available in all pharmacies in Bangladesh
Approval Status
Approved by DGDA, Bangladesh
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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