Inket
Generic Name
Ketorolac Tromethamine
Manufacturer
ACI Limited
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| inket 10 mg tablet | ৳ 10.00 | N/A |
Description
Overview of the medicine
Inket (Ketorolac Tromethamine) is a potent non-steroidal anti-inflammatory drug (NSAID) used for the short-term management of moderately severe acute pain that requires analgesia at the opioid level.
Uses & Indications
Dosage
Adults
Oral: 10 mg every 4-6 hours, not to exceed 40 mg/day. Maximum duration 5 days.
Elderly
Lower doses may be required, e.g., 10 mg every 6-8 hours, not to exceed 40 mg/day. Maximum duration 5 days.
Renal_impairment
Reduced dosage (e.g., 10 mg every 6-8 hours) or avoided in severe impairment. Maximum 20 mg/day.
How to Take
Tablets should be swallowed whole with water, with or after food to minimize gastrointestinal upset.
Mechanism of Action
Ketorolac inhibits prostaglandin synthesis by reversibly inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing inflammation, pain, and fever.
Pharmacokinetics
Onset
Within 30-60 minutes
Excretion
Mainly renal (approximately 90%), with a small amount in feces.
Half life
Approximately 5-6 hours
Absorption
Rapidly and completely absorbed after oral administration. Peak plasma concentrations achieved in 30-60 minutes.
Metabolism
Primarily hepatic, via hydroxylation and conjugation.
Side Effects
Contraindications
- Hypersensitivity to ketorolac or other NSAIDs
- Active peptic ulcer, gastrointestinal bleeding, or perforation
- Severe renal impairment
- Advanced heart failure
- Cerebrovascular bleeding
- Coagulation disorders
- Pregnancy and lactation
- Peri-operative pain in CABG surgery
Drug Interactions
Warfarin, Heparin
Increased risk of bleeding.
Lithium, Methotrexate
Increased plasma levels of these drugs, leading to toxicity.
Diuretics, ACE inhibitors
Reduced efficacy of these drugs, increased risk of renal impairment.
Other NSAIDs, Corticosteroids
Increased risk of GI side effects.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, epigastric pain, lethargy. Management is supportive and symptomatic; gastric lavage and activated charcoal may be considered if recent. Hemodialysis is not effective.
Pregnancy & Lactation
Contraindicated in pregnancy (especially third trimester due to risk of premature closure of ductus arteriosus) and lactation.
Side Effects
Contraindications
- Hypersensitivity to ketorolac or other NSAIDs
- Active peptic ulcer, gastrointestinal bleeding, or perforation
- Severe renal impairment
- Advanced heart failure
- Cerebrovascular bleeding
- Coagulation disorders
- Pregnancy and lactation
- Peri-operative pain in CABG surgery
Drug Interactions
Warfarin, Heparin
Increased risk of bleeding.
Lithium, Methotrexate
Increased plasma levels of these drugs, leading to toxicity.
Diuretics, ACE inhibitors
Reduced efficacy of these drugs, increased risk of renal impairment.
Other NSAIDs, Corticosteroids
Increased risk of GI side effects.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, epigastric pain, lethargy. Management is supportive and symptomatic; gastric lavage and activated charcoal may be considered if recent. Hemodialysis is not effective.
Pregnancy & Lactation
Contraindicated in pregnancy (especially third trimester due to risk of premature closure of ductus arteriosus) and lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensively studied for short-term acute pain management in various surgical and medical conditions. Clinical trials have demonstrated efficacy comparable to opioids for acute pain, with differing side effect profiles.
Lab Monitoring
- Renal function (BUN, creatinine)
- Liver function tests (ALT, AST)
- Complete Blood Count (CBC) including platelets (if long-term use or high risk)
- Blood pressure monitoring
Doctor Notes
- Prescribe for shortest duration possible (maximum 5 days).
- Assess renal and cardiovascular risk factors before prescribing.
- Concomitant use with anticoagulants requires careful monitoring.
- Not suitable for chronic pain management.
Patient Guidelines
- Do not exceed recommended dose or duration (maximum 5 days).
- Report any signs of stomach bleeding (black stools, vomiting blood).
- Avoid alcohol and other NSAIDs while taking this medicine.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Driving Precautions
May cause dizziness, drowsiness, or visual disturbances. Advise patients to avoid driving or operating machinery if affected.
Lifestyle Advice
- Avoid strenuous activities if experiencing dizziness or drowsiness.
- Stay hydrated.
- Follow a balanced diet.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Inket Brand
Other medicines available under the same brand name
