Inoxon
Generic Name
Inoxon 500 mg Injection
Manufacturer
Generic Pharma Co.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| inoxon 500 mg injection | ৳ 120.00 | N/A |
Description
Overview of the medicine
Inoxon 500 mg Injection is a broad-spectrum carbapenem antibiotic used to treat a wide range of severe bacterial infections in adults and children, including pneumonia, urinary tract infections, intra-abdominal infections, skin and soft tissue infections, meningitis, and sepsis. It contains Meropenem and is administered intravenously.
Uses & Indications
Dosage
Adults
Typically 500 mg to 1 g intravenously every 8 hours, depending on the severity and type of infection. For bacterial meningitis or severe infections, 1 g every 8 hours is common.
Elderly
Dosage adjustment may be necessary based on renal function.
Renal_impairment
Reduced dosage is required. For CrCl 26-50 mL/min: 500 mg every 12 hours; for CrCl 10-25 mL/min: 250 mg every 12 hours; for CrCl <10 mL/min: 250 mg every 24 hours.
How to Take
Administered by slow intravenous (IV) injection over 3-5 minutes or by intravenous infusion over 15-30 minutes. Reconstitution instructions must be followed carefully by a healthcare professional.
Mechanism of Action
Meropenem exerts its bactericidal activity by interfering with bacterial cell wall synthesis. It readily penetrates the bacterial cell wall to reach penicillin-binding protein (PBP) targets, causing inhibition of cell wall synthesis and subsequent bacterial cell lysis and death.
Pharmacokinetics
Onset
Rapid, typically within minutes of IV infusion.
Excretion
Primarily excreted unchanged in the urine (approximately 70% within 12 hours).
Half life
Approximately 1 hour.
Absorption
Rapid and complete absorption after intravenous administration.
Metabolism
Minimal hepatic metabolism, primarily hydrolyzed by dehydropeptidase-I (DHP-I), though meropenem is relatively stable to DHP-I.
Side Effects
Contraindications
- Hypersensitivity to meropenem, any other carbapenem antibiotic, or any component of the formulation
- Severe hypersensitivity (e.g., anaphylactic reaction, severe skin reaction) to any other beta-lactam antibacterial agent (e.g., penicillins or cephalosporins)
Drug Interactions
Probenecid
Inhibits renal tubular secretion of meropenem, increasing its plasma concentration and prolonging its half-life. Concomitant administration is not recommended.
Valproic Acid/Sodium Valproate
May significantly decrease valproic acid plasma concentrations, leading to loss of seizure control. Concomitant use is generally not recommended.
Storage
Store below 25°C in the original package to protect from light. Do not freeze. Reconstituted solutions should be used immediately or stored according to specific guidelines (e.g., for a limited time under refrigeration).
Overdose
Limited experience with overdose. Symptoms may include nausea, vomiting, diarrhea, seizures. Treatment is symptomatic and supportive. Hemodialysis can remove meropenem from the circulation.
Pregnancy & Lactation
Pregnancy category B. Use during pregnancy only if clearly needed. Meropenem is excreted in small amounts in human milk; use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to meropenem, any other carbapenem antibiotic, or any component of the formulation
- Severe hypersensitivity (e.g., anaphylactic reaction, severe skin reaction) to any other beta-lactam antibacterial agent (e.g., penicillins or cephalosporins)
Drug Interactions
Probenecid
Inhibits renal tubular secretion of meropenem, increasing its plasma concentration and prolonging its half-life. Concomitant administration is not recommended.
Valproic Acid/Sodium Valproate
May significantly decrease valproic acid plasma concentrations, leading to loss of seizure control. Concomitant use is generally not recommended.
Storage
Store below 25°C in the original package to protect from light. Do not freeze. Reconstituted solutions should be used immediately or stored according to specific guidelines (e.g., for a limited time under refrigeration).
Overdose
Limited experience with overdose. Symptoms may include nausea, vomiting, diarrhea, seizures. Treatment is symptomatic and supportive. Hemodialysis can remove meropenem from the circulation.
Pregnancy & Lactation
Pregnancy category B. Use during pregnancy only if clearly needed. Meropenem is excreted in small amounts in human milk; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date when stored unopened.
Availability
Hospitals, Clinics, Retail pharmacies with prescription
Approval Status
Approved by relevant regulatory authorities for parenteral use.
Patent Status
Generic available (original patent expired)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established meropenem's efficacy and safety in various bacterial infections, including those resistant to other antibiotics. Ongoing post-marketing surveillance and new trials continue to evaluate its role.
Lab Monitoring
- Renal function (creatinine, BUN) in patients with impaired kidney function
- Liver function tests (ALT, AST, bilirubin) periodically
- Complete blood count (CBC) during prolonged therapy
- Therapeutic drug monitoring (TDM) may be considered in critically ill patients, although not routinely performed.
Doctor Notes
- Crucial for severe, life-threatening infections, especially in ICU settings or when multi-drug resistant organisms are suspected.
- Careful monitoring of renal function is essential, particularly in elderly or renally impaired patients.
- Be aware of potential for seizures, especially in patients with pre-existing CNS disorders.
Patient Guidelines
- Inform your doctor about any allergies, especially to antibiotics.
- Complete the full course of treatment even if you feel better.
- Report any severe diarrhea or allergic reactions immediately.
- Do not use for viral infections (e.g., common cold, flu).
Missed Dose Advice
If a dose is missed, it should be administered as soon as remembered, unless it is almost time for the next scheduled dose. In that case, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Inoxon may cause side effects like dizziness or seizures which could impair your ability to drive or operate machinery. Exercise caution until you know how the medicine affects you.
Lifestyle Advice
- Maintain good hydration during treatment.
- Avoid alcohol consumption during antibiotic therapy if experiencing gastrointestinal side effects.
- Follow your doctor's instructions regarding diet and activity.
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