Ivacure
Generic Name
Ivermectin
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ivacure 3 mg tablet | ৳ 6.00 | ৳ 60.00 |
Description
Overview of the medicine
Ivacure 3 mg tablet is an anti-parasitic medication used to treat certain parasitic infections in humans, such as strongyloidiasis and onchocerciasis.
Uses & Indications
Dosage
Adults
Strongyloidiasis: A single oral dose of 200 mcg/kg body weight. Onchocerciasis: A single oral dose of 150 mcg/kg body weight every 6 to 12 months. Scabies: A single oral dose of 200 mcg/kg, repeated in 7-14 days if needed.
Elderly
No specific dose adjustments needed, but use with caution due to potential for comorbidities and polypharmacy. Dosing typically follows adult recommendations based on body weight.
Renal_impairment
No dosage adjustment needed for mild to moderate renal impairment. Caution advised in severe renal impairment.
How to Take
Take the tablet orally with water on an empty stomach (at least 1 hour before or 2 hours after a meal).
Mechanism of Action
Ivermectin binds selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions and subsequent hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite.
Pharmacokinetics
Onset
Pharmacological effects may begin within hours, but clinical efficacy against parasites may take days to weeks depending on the infection.
Excretion
Excreted almost exclusively in the feces over approximately 12 days, with less than 1% excreted in the urine.
Half life
Plasma elimination half-life is approximately 12-36 hours, but can be longer.
Absorption
Readily absorbed after oral administration. Peak plasma concentrations are reached approximately 4-5 hours post-dose. Absorption can be enhanced with a high-fat meal.
Metabolism
Primarily metabolized in the liver, mainly by CYP3A4, into at least 10 metabolites.
Side Effects
Contraindications
- Hypersensitivity to Ivermectin or any component of the tablet.
- Not recommended for children under 15 kg body weight for most indications.
- Pregnancy and lactation (relative contraindication).
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin, requiring close monitoring of INR.
CNS Depressants
Concurrent use with other CNS depressants may increase CNS depression (e.g., benzodiazepines, barbiturates).
CYP3A4 Inhibitors/Inducers
Drugs affecting CYP3A4 may alter ivermectin metabolism, though clinical significance is generally minor.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include rash, edema, headache, dizziness, asthenia, nausea, vomiting, diarrhea, abdominal pain, seizures, ataxia, dyspnea, and coma. Treatment is supportive and symptomatic, involving gastric lavage and general supportive therapy.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Ivermectin is excreted in human milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to Ivermectin or any component of the tablet.
- Not recommended for children under 15 kg body weight for most indications.
- Pregnancy and lactation (relative contraindication).
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin, requiring close monitoring of INR.
CNS Depressants
Concurrent use with other CNS depressants may increase CNS depression (e.g., benzodiazepines, barbiturates).
CYP3A4 Inhibitors/Inducers
Drugs affecting CYP3A4 may alter ivermectin metabolism, though clinical significance is generally minor.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include rash, edema, headache, dizziness, asthenia, nausea, vomiting, diarrhea, abdominal pain, seizures, ataxia, dyspnea, and coma. Treatment is supportive and symptomatic, involving gastric lavage and general supportive therapy.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Ivermectin is excreted in human milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Usually 24-36 months from the date of manufacture.
Availability
Available in pharmacies
Approval Status
Approved by regulatory authorities (e.g., DGDA)
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Ivermectin has been extensively studied in clinical trials for its approved indications. There have also been numerous trials for off-label uses, including COVID-19, with mixed and often inconclusive results.
Lab Monitoring
- No routine laboratory monitoring is typically required.
- Liver function tests may be considered in patients with pre-existing hepatic impairment or if symptoms suggest liver dysfunction.
Doctor Notes
- Ensure accurate diagnosis of parasitic infection before prescribing.
- Emphasize patient adherence to the single-dose regimen or repeated doses as per specific indication.
- Monitor for signs of systemic adverse reactions, especially in patients with high parasitic burden.
Patient Guidelines
- Take the full course of medication as prescribed, even if symptoms improve.
- Do not crush, chew, or break the tablet; swallow it whole.
- Report any severe or persistent side effects to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Ivacure may cause dizziness, lightheadedness, or drowsiness. Patients should exercise caution when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Practice good hygiene to prevent re-infection, especially for parasitic worm infections.
- Avoid consumption of raw or undercooked meat.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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