Ivacure
Generic Name
Ivermectin
Manufacturer
Healthcare Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ivacure 6 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Ivacure 6 mg Tablet contains Ivermectin, an antiparasitic medication used to treat various parasitic infections, including scabies, strongyloidiasis, onchocerciasis, and lymphatic filariasis. It works by paralyzing and killing parasites.
Uses & Indications
Dosage
Adults
Strongyloidiasis: 200 mcg/kg body weight as a single oral dose. Scabies: 200 mcg/kg body weight as a single oral dose, repeated after 7-14 days if needed. Onchocerciasis: 150 mcg/kg body weight as a single oral dose, usually repeated every 3-12 months.
Elderly
No specific dose adjustment is generally required, but caution is advised due to potential age-related decrease in hepatic function and polypharmacy.
Renal_impairment
No specific dose adjustment is recommended as less than 1% is excreted renally. However, use with caution in severe impairment.
How to Take
Take the tablet orally with water, usually on an empty stomach (e.g., 1 hour before a meal) for optimal absorption. For scabies, a single dose is often sufficient, but a second dose may be needed.
Mechanism of Action
Ivermectin selectively binds with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions, resulting in hyperpolarization of the nerve or muscle cell, and subsequent paralysis and death of the parasite.
Pharmacokinetics
Onset
Within hours for antiparasitic effect, but clinical symptom resolution varies depending on the infection.
Excretion
Almost exclusively in feces over approximately 12 days, with less than 1% excreted in urine.
Half life
Approximately 12-36 hours (mean 18 hours).
Absorption
Well absorbed after oral administration; bioavailability is approximately 20-30% and can be increased with a high-fat meal.
Metabolism
Primarily hepatic, via CYP3A4, to various hydroxylated metabolites.
Side Effects
Contraindications
- Hypersensitivity to Ivermectin or any component of the tablet.
- Use in children weighing less than 15 kg.
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin, requiring INR monitoring.
Other GABA agonists (e.g., benzodiazepines, barbiturates)
May potentiate GABAergic effects, leading to increased sedation or CNS depression.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include rash, edema, headache, dizziness, asthenia, nausea, vomiting, diarrhea, and abdominal pain. In severe cases, seizures and coma have been reported. Management involves supportive care and symptomatic treatment.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. It is excreted in human milk; therefore, use with caution during lactation or avoid breastfeeding for a period after dosing.
Side Effects
Contraindications
- Hypersensitivity to Ivermectin or any component of the tablet.
- Use in children weighing less than 15 kg.
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin, requiring INR monitoring.
Other GABA agonists (e.g., benzodiazepines, barbiturates)
May potentiate GABAergic effects, leading to increased sedation or CNS depression.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include rash, edema, headache, dizziness, asthenia, nausea, vomiting, diarrhea, and abdominal pain. In severe cases, seizures and coma have been reported. Management involves supportive care and symptomatic treatment.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. It is excreted in human milk; therefore, use with caution during lactation or avoid breastfeeding for a period after dosing.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture, check package for exact expiry.
Availability
Available in pharmacies and hospitals nationwide
Approval Status
Approved (DGDA, Bangladesh)
Patent Status
Patent expired for generic Ivermectin
WHO Essential Medicine
YesClinical Trials
Ivermectin has undergone extensive clinical trials supporting its efficacy and safety for approved indications. Ongoing research explores its potential in other areas.
Lab Monitoring
- No routine lab monitoring is required for most indications. Liver function tests may be considered in patients with pre-existing hepatic impairment.
Doctor Notes
- Advise patients to take the tablet on an empty stomach for optimal absorption.
- Caution patients about potential dizziness and drowsiness.
- For scabies, emphasize the importance of treating close contacts and environmental disinfection to prevent re-infestation.
Patient Guidelines
- Follow your doctor's instructions regarding dosage and administration.
- Take the tablet on an empty stomach with water.
- Do not take a double dose to make up for a missed one.
- Report any severe or persistent side effects to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Ivacure may cause dizziness, drowsiness, or blurred vision. Avoid driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain good hygiene practices, especially for conditions like scabies, to prevent re-infection.
- Avoid contact with infected persons or animals.
- Ensure proper sanitation in your living environment.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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