Janvia
Generic Name
Sitagliptin
Manufacturer
Healthcare Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| janvia 50 mg tablet | ৳ 15.04 | ৳ 150.40 |
Description
Overview of the medicine
Janvia 50 mg tablet contains Sitagliptin, an oral anti-diabetic drug used to improve blood sugar control in adults with type 2 diabetes mellitus. It is used as an adjunct to diet and exercise.
Uses & Indications
Dosage
Adults
The usual recommended dose is 100 mg once daily. For the 50 mg tablet, it may be used in patients with moderate renal impairment or as per physician's discretion.
Elderly
No dose adjustment is required based on age alone. However, renal function should be assessed before initiating treatment and periodically thereafter.
Renal_impairment
For moderate renal impairment (CrCl ≥30 to <50 mL/min), the recommended dose is 50 mg once daily. For severe renal impairment (CrCl <30 mL/min) or end-stage renal disease requiring dialysis, the recommended dose is 25 mg once daily.
How to Take
Janvia 50 mg tablet should be taken orally once daily, with or without food. Swallow the tablet whole with water.
Mechanism of Action
Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It increases the levels of active incretin hormones (glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)), which are released by the intestine throughout the day and increase in response to meals. Incretins enhance glucose-dependent insulin secretion from pancreatic beta cells and decrease glucagon secretion from pancreatic alpha cells. This leads to improved glycemic control.
Pharmacokinetics
Onset
Glycemic effects typically observed within a few hours of administration.
Excretion
Primarily renal excretion (approximately 79% unchanged in urine), with a minor portion excreted in feces.
Half life
The elimination half-life is approximately 12.4 hours.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations (Tmax) achieved in 1 to 4 hours. Absolute oral bioavailability is approximately 87%.
Metabolism
Approximately 79% of Sitagliptin is excreted unchanged in the urine. Limited metabolism occurs, primarily via CYP3A4, with minor contribution from CYP2C8.
Side Effects
Contraindications
- •Hypersensitivity to sitagliptin or any component of the tablet.
- •History of serious hypersensitivity reactions to a DPP-4 inhibitor, such as anaphylaxis or angioedema.
Drug Interactions
Digoxin
A slight increase in digoxin plasma levels has been observed when co-administered with sitagliptin, but no dose adjustment is typically needed.
Cyclosporine
Coadministration with cyclosporine may increase sitagliptin exposure, but clinical significance is generally minimal.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of the reach and sight of children.
Overdose
In the event of an overdose, it is reasonable to employ standard supportive measures (e.g., remove unabsorbed material from the gastrointestinal tract, employ clinical monitoring, and institute supportive treatment as dictated by the patient’s clinical status). Sitagliptin is modestly dialyzable.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. There are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. It is unknown whether sitagliptin is excreted in human milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years from the date of manufacture, specific details are on the packaging.
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Expired for generic Sitagliptin in many markets
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Global Brand Names
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