For external use only. Apply a thin layer of gel to the affected skin area and gently rub it in. Wash hands thoroughly after application, unless the hands are the treated area. Do not cover with occlusive bandages.

Diclofenac works by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, which are responsible for the synthesis of prostaglandins. Prostaglandins are mediators of inflammation, pain, and fever. By reducing prostaglandin synthesis, diclofenac alleviates pain and inflammation. When applied topically, it exerts its effects locally at the site of application.

• •Hypersensitivity to diclofenac, aspirin, other NSAIDs, or any components of the gel.
• •Patients with asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
• •Application to open wounds, infected skin, or dermatitis.
• •Third trimester of pregnancy.

Store below 30°C. Do not freeze. Keep out of reach of children.

Due to low systemic absorption, an overdose from topical application is unlikely. If accidentally ingested or if excessive amounts are applied over large areas, systemic adverse effects similar to oral NSAIDs might occur. Treatment is supportive and symptomatic; gastric emptying might be considered if recent ingestion.

Pregnancy: Category C in first and second trimesters, D in third trimester (due to risk of premature closure of fetal ductus arteriosus). Use during the first two trimesters only if clearly needed. Contraindicated in the third trimester. Lactation: Diclofenac is excreted in breast milk in small amounts after oral administration. Systemic absorption after topical application is low, so risk to breastfed infant is considered low, but use with caution and under medical advice.