juvain
Generic Name
Paracetamol (Acetaminophen)
Manufacturer
Medico Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| juvain 500 mg syrup | ৳ 150.57 | N/A |
Description
Overview of the medicine
Juvain 500 mg Syrup (Paracetamol) is used for the relief of mild to moderate pain and to reduce fever. Each 5 mL of syrup contains 250 mg of Paracetamol. A 10 mL dose would contain 500 mg of Paracetamol.
Uses & Indications
Dosage
Adults
Oral: 500 mg (10 mL) to 1000 mg (20 mL) every 4-6 hours as needed. Maximum 4000 mg (80 mL) in 24 hours.
Elderly
Same as adults, but caution is advised in patients with impaired hepatic or renal function.
Renal_impairment
Dose adjustment may be necessary; consult a physician. Extended dosing interval may be required (e.g., every 6-8 hours).
How to Take
Juvain 500 mg Syrup is for oral administration. It can be taken with or without food. Use a measuring spoon or cup to ensure accurate dosing.
Mechanism of Action
Paracetamol is thought to act primarily in the central nervous system by inhibiting prostaglandin synthesis, possibly through a central cyclooxygenase (COX-3) mechanism. It also has an antipyretic effect by direct action on the heat-regulating centers of the hypothalamus.
Pharmacokinetics
Onset
Onset of action for pain relief is typically within 30-60 minutes.
Excretion
Mainly excreted in the urine as glucuronide and sulfate conjugates, with less than 5% excreted as unchanged drug.
Half life
Plasma elimination half-life is approximately 1-4 hours.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 10-60 minutes.
Metabolism
Primarily metabolized in the liver via glucuronide and sulfate conjugation, and a small amount by oxidation via cytochrome P450 enzymes to a highly reactive intermediate (NAPQI) which is detoxified by glutathione.
Side Effects
Contraindications
- •Known hypersensitivity to Paracetamol or any other component of the syrup
- •Severe hepatic impairment or active liver disease
Drug Interactions
Alcohol
Chronic alcohol consumption increases the risk of hepatotoxicity.
Warfarin
May enhance the anticoagulant effect of warfarin, increasing the risk of bleeding with prolonged use or high doses.
Cholestyramine
Reduces the absorption of Paracetamol if taken within one hour.
Certain anti-epileptics (e.g., Phenytoin, Carbamazepine)
May reduce the therapeutic effect of Paracetamol and increase its hepatotoxicity.
Storage
Store below 30°C. Protect from light and moisture. Keep in a cool, dry place. Do not freeze.
Overdose
Paracetamol overdose can cause severe liver damage, potentially fatal. Symptoms may include nausea, vomiting, abdominal pain, and sweating. In case of suspected overdose, seek immediate medical attention. N-acetylcysteine (NAC) is the antidote and should be administered as soon as possible.
Pregnancy & Lactation
Paracetamol is generally considered safe for use during pregnancy and breastfeeding at recommended doses. It is often the preferred analgesic. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years from the date of manufacture, when stored according to recommendations.
Availability
Pharmacies, supermarkets, general stores
Approval Status
Globally approved and widely available
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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