Kepronol
Generic Name
Propranolol
Manufacturer
Square Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| kepronol 05 eye drop | ৳ 80.00 | N/A |
Description
Overview of the medicine
Kepronol (Propranolol) is a non-selective beta-adrenergic blocker used to treat various conditions including high blood pressure, angina, arrhythmia, and migraine prophylaxis.
Uses & Indications
Dosage
Adults
Typical starting dose for hypertension is 40 mg twice daily; may be increased to 120-240 mg/day.
Elderly
Lower initial doses may be considered, monitor carefully for adverse effects.
Renal_impairment
No dosage adjustment typically required, but use with caution in severe impairment.
How to Take
Administer orally, preferably before meals or on an empty stomach to ensure consistent absorption.
Mechanism of Action
Blocks beta-1 and beta-2 adrenergic receptors, leading to decreased heart rate, reduced cardiac output, and lowered blood pressure.
Pharmacokinetics
Onset
Oral: 30 minutes
Excretion
Primarily via urine as metabolites.
Half life
3-6 hours (immediate release)
Absorption
Well absorbed from the GI tract; extensive first-pass metabolism.
Metabolism
Extensively metabolized in the liver via glucuronidation and aromatic hydroxylation.
Side Effects
Contraindications
- •Bronchial asthma or bronchospasm
- •Cardiogenic shock
- •Sinus bradycardia
- •Second or third-degree AV block
- •Untreated pheochromocytoma
- •Metabolic acidosis
Drug Interactions
NSAIDs
May reduce antihypertensive effect
Alcohol
May increase propranolol levels
Cimetidine
Increases propranolol levels
MAO inhibitors
Hypertensive crisis
Calcium channel blockers
Increased risk of bradycardia and hypotension
Storage
Store below 30°C in a dry place, away from light and moisture.
Overdose
Symptoms include bradycardia, hypotension, bronchospasm, heart failure. Treatment is supportive, including atropine for bradycardia, glucagon, and vasopressors.
Pregnancy & Lactation
Category C (risk cannot be ruled out). Use only if potential benefit justifies potential risk to the fetus. Excreted in breast milk, use with caution.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies and hospitals
Approval Status
Approved by major regulatory bodies
Patent Status
Generic available, patent expired
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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