Keteks
Generic Name
Ketorolac Tromethamine
Manufacturer
MediCare Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| keteks 10 mg tablet | ৳ 30.00 | ৳ 300.00 |
Description
Overview of the medicine
Keteks 10 mg Tablet contains Ketorolac Tromethamine, a non-steroidal anti-inflammatory drug (NSAID). It is primarily used for the short-term management of moderately severe acute pain that requires analgesia at the opioid level. It is not indicated for chronic pain conditions.
Uses & Indications
Dosage
Adults
Oral: 10 mg every 4 to 6 hours as needed, not to exceed 40 mg in 24 hours. Therapy duration should not exceed 5 days.
Elderly
Use the lowest effective dose for the shortest duration. Dosage reduction may be necessary.
Renal_impairment
Reduce dosage by 50% (e.g., 5 mg every 6 hours) in patients with moderate to severe renal impairment. Contraindicated in severe renal failure.
How to Take
Take the tablet orally with a full glass of water. It can be taken with or without food. Do not crush, chew, or break the tablet.
Mechanism of Action
Ketorolac Tromethamine exerts its analgesic, anti-inflammatory, and antipyretic effects primarily by inhibiting prostaglandin synthesis through the inhibition of cyclooxygenase (COX-1 and COX-2) enzymes. This reduces the formation of prostaglandin precursors that contribute to pain and inflammation.
Pharmacokinetics
Onset
Analgesia typically begins within 30-60 minutes.
Excretion
Approximately 92% is excreted in the urine (60% as metabolites, 40% as unchanged drug) and 6% in feces.
Half life
Approximately 4-6 hours.
Absorption
Rapidly and completely absorbed orally. Peak plasma concentrations are achieved in approximately 30-60 minutes after a single oral dose.
Metabolism
Extensively metabolized in the liver, primarily via glucuronidation and to a lesser extent by hydroxylation.
Side Effects
Contraindications
- •Hypersensitivity to Ketorolac or other NSAIDs
- •Active peptic ulcer, recent gastrointestinal bleeding or perforation
- •Advanced renal impairment or at risk of renal failure
- •Severe heart failure
- •History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- •Coagulation disorders or patients on anticoagulants
- •Cerebrovascular bleeding or suspected bleeding
- •Concomitant use with other NSAIDs, oxpentifylline, probenecid, or lithium
- •As prophylactic analgesia before major surgery or during surgery
- •During labor and delivery
- •Breastfeeding
- •Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels, leading to potential toxicity.
Probenecid
Significantly increases Ketorolac plasma levels and half-life; concomitant use is contraindicated.
Methotrexate
Increased plasma methotrexate levels, leading to enhanced toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Other NSAIDs or Aspirin
Increased risk of gastrointestinal adverse effects and bleeding.
Diuretics (e.g., Furosemide)
Reduced diuretic and hypotensive effects, increased risk of renal impairment.
Oxpentifylline (Pentoxifylline)
Increased risk of bleeding; concomitant use is contraindicated.
Anticoagulants (e.g., Warfarin, Heparin)
Increased risk of severe bleeding.
ACE Inhibitors / Angiotensin II Receptor Blockers (ARBs)
Reduced hypotensive effects, increased risk of renal impairment, especially in elderly, volume-depleted, or renally impaired patients.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric pain, lethargy, drowsiness, and, rarely, gastrointestinal bleeding, acute renal failure, or respiratory depression. Management is primarily symptomatic and supportive. Gastric lavage or activated charcoal may be considered within 1 hour of ingestion. Monitor renal function and electrolyte balance.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters); Category D (third trimester). Ketorolac is contraindicated in the third trimester of pregnancy due to the risk of premature closure of the fetal ductus arteriosus and potential inhibition of uterine contractions. Ketorolac is contraindicated during labor, delivery, and breastfeeding due to potential adverse effects on the infant and inhibition of uterine contractions.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent expired (generic available)
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Global Brand Names
International brand names for this medicine
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