Oral tablets should be taken with food to improve absorption. Topical cream/shampoo for external use only, apply to affected area after cleaning.

Ketoconazole inhibits the fungal cytochrome P450 enzyme 14α-demethylase, which is involved in the biosynthesis of ergosterol, a vital component of fungal cell membranes. Inhibition of ergosterol synthesis leads to increased permeability of the fungal cell membrane, resulting in leakage of cellular contents and ultimately cell death.

• •Hypersensitivity to ketoconazole or other azole antifungals
• •Acute or chronic liver disease (oral)
• •Concomitant use with certain CYP3A4 substrates (e.g., terfenadine, astemizole, cisapride, quinidine, dofetilide, pimozide, HMG-CoA reductase inhibitors like simvastatin) due to risk of serious cardiac arrhythmias (oral)

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Symptoms may include nausea, vomiting, abdominal pain, and liver dysfunction. Treatment is symptomatic and supportive. Gastric lavage may be considered.

Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Small amounts may pass into breast milk; use with caution.