Take orally with food to ensure maximal absorption and to minimize gastrointestinal upset. It requires an acidic environment for absorption, so avoid antacids, H2-blockers, and proton pump inhibitors (PPIs) within 2 hours of taking Ketocid.

Ketoconazole inhibits the fungal cytochrome P450 enzyme 14α-demethylase, which is responsible for the demethylation of lanosterol to ergosterol. Ergosterol is a vital component of the fungal cell membrane, and its inhibition leads to increased cell membrane permeability and leakage of cellular contents, ultimately leading to fungal cell death.

• •Hypersensitivity to ketoconazole or any component of the formulation.
• •Acute or chronic hepatic disease.
• •Concomitant use with drugs that prolong QT interval and are metabolized by CYP3A4 (e.g., cisapride, dofetilide, quinidine, pimozide, ergot alkaloids, midazolam, triazolam, statins like lovastatin, simvastatin).

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

In case of overdose, supportive measures should be initiated. Gastric lavage may be considered if ingestion is recent. Monitor liver function closely and manage symptoms symptomatically.

Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk; therefore, caution should be exercised when administered to a nursing mother. It is generally not recommended during breastfeeding.