Ketolab
Generic Name
Ketorolac Tromethamine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ketolab 30 mg injection | ৳ 75.00 | N/A |
Description
Overview of the medicine
Ketolab 30 mg Injection contains ketorolac tromethamine, a potent non-steroidal anti-inflammatory drug (NSAID) primarily used for the short-term management of moderately severe acute pain. It works by reducing hormones that cause pain and inflammation in the body.
Uses & Indications
Dosage
Adults
Typically 30 mg IM or IV every 6 hours as needed, not to exceed 120 mg/day for a maximum of 5 days.
Elderly
Reduced dosage, e.g., 15 mg IM or IV every 6 hours, not to exceed 60 mg/day.
Renal_impairment
Significant dosage reduction required; often contraindicated in severe impairment. Max 30 mg/day.
How to Take
For intramuscular (IM) or intravenous (IV) administration. IV bolus should be administered over at least 15 seconds. IM injection should be given slowly and deeply into a large muscle. Not for epidural or intrathecal administration.
Mechanism of Action
Ketorolac tromethamine inhibits prostaglandin synthesis by reversibly blocking the cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes. This inhibition reduces the formation of prostaglandins, which are mediators of pain, inflammation, and fever.
Pharmacokinetics
Onset
Analgesia usually begins within 10 minutes of IV administration, 30-60 minutes of IM administration.
Excretion
Primarily renal (90%), with a small amount excreted in feces.
Half life
Approximately 5-6 hours.
Absorption
Rapid and complete absorption after intramuscular (IM) administration. Peak plasma concentrations are achieved within 30-60 minutes.
Metabolism
Primarily hepatic via glucuronidation and hydroxylation.
Side Effects
Contraindications
- Hypersensitivity to ketorolac or other NSAIDs
- Active peptic ulcer disease or gastrointestinal bleeding
- Advanced renal impairment
- Cerebrovascular bleeding or suspected bleeding
- Pregnancy (late-term) and lactation
- Children under 16 years
- Prophylactic use before major surgery
Drug Interactions
Lithium
Increased lithium levels and toxicity.
Methotrexate
Increased methotrexate toxicity.
ACE Inhibitors/ARBs
Increased risk of renal impairment, reduced antihypertensive effect.
Diuretics (furosemide)
Reduced diuretic and antihypertensive effect.
Anticoagulants (warfarin)
Increased risk of bleeding.
Storage
Store below 30°C, protected from light and moisture. Do not freeze.
Overdose
Symptoms include epigastric pain, nausea, vomiting, lethargy, drowsiness. Management involves symptomatic and supportive care. Gastric lavage/activated charcoal may be considered if recent ingestion.
Pregnancy & Lactation
Pregnancy: Category C (first and second trimesters), Category D (third trimester due to risk of premature closure of ductus arteriosus). Should be avoided. Lactation: Excreted in breast milk, should be avoided.
Side Effects
Contraindications
- Hypersensitivity to ketorolac or other NSAIDs
- Active peptic ulcer disease or gastrointestinal bleeding
- Advanced renal impairment
- Cerebrovascular bleeding or suspected bleeding
- Pregnancy (late-term) and lactation
- Children under 16 years
- Prophylactic use before major surgery
Drug Interactions
Lithium
Increased lithium levels and toxicity.
Methotrexate
Increased methotrexate toxicity.
ACE Inhibitors/ARBs
Increased risk of renal impairment, reduced antihypertensive effect.
Diuretics (furosemide)
Reduced diuretic and antihypertensive effect.
Anticoagulants (warfarin)
Increased risk of bleeding.
Storage
Store below 30°C, protected from light and moisture. Do not freeze.
Overdose
Symptoms include epigastric pain, nausea, vomiting, lethargy, drowsiness. Management involves symptomatic and supportive care. Gastric lavage/activated charcoal may be considered if recent ingestion.
Pregnancy & Lactation
Pregnancy: Category C (first and second trimesters), Category D (third trimester due to risk of premature closure of ductus arteriosus). Should be avoided. Lactation: Excreted in breast milk, should be avoided.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date.
Availability
Pharmacies, Hospitals, Clinics
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated efficacy and safety in acute pain management. Ongoing research explores new indications and formulations.
Lab Monitoring
- Complete blood count (CBC)
- Renal function (creatinine, BUN)
- Liver function tests (ALT, AST) especially during prolonged therapy
Doctor Notes
- For short-term (max 5 days) use only for acute, moderately severe pain.
- Assess renal function before and during therapy, especially in elderly or compromised patients.
- Concomitant use with other NSAIDs, aspirin, or anticoagulants is contraindicated.
Patient Guidelines
- Do not use for more than 5 days.
- Report any signs of gastrointestinal bleeding (black, tarry stools, coffee-ground vomit).
- Inform your doctor about all other medications you are taking.
- Avoid alcohol while using this medicine.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness, drowsiness, or visual disturbances. Advise caution when driving or operating machinery.
Lifestyle Advice
- Avoid activities requiring mental alertness if experiencing dizziness or drowsiness.
- Maintain adequate hydration.
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Global Brand Names
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