Ketovir
Generic Name
Ketorolac
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ketovir 10 mg tablet | ৳ 10.00 | N/A |
Description
Overview of the medicine
Ketorolac (marketed as Ketovir) is a nonsteroidal anti-inflammatory drug (NSAID) used for the short-term treatment of moderately severe acute pain that requires analgesia at the opioid level. It is available in oral, injectable, and ophthalmic forms.
Uses & Indications
Dosage
Adults
Oral: 10 mg every 4-6 hours as needed, not to exceed 40 mg/day. Max duration 5 days.
Elderly
Lower doses may be required, e.g., 10 mg every 6-8 hours, max 30 mg/day.
Renal_impairment
Reduced dosage is necessary, often contraindicated in severe impairment.
How to Take
Oral tablets should be taken with food or milk to reduce gastrointestinal irritation. Injection is for IM or IV use.
Mechanism of Action
Ketorolac inhibits prostaglandin synthesis by reversibly blocking the cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes. This leads to a reduction in inflammation, pain, and fever.
Pharmacokinetics
Onset
Within 1 hour for oral, 30 minutes for IM.
Excretion
Primarily renal (approximately 90%), some through feces.
Half life
Approximately 4-6 hours (can be longer in elderly or renal impairment).
Absorption
Rapid and complete after oral administration. Peak plasma concentrations reached within 30-60 minutes.
Metabolism
Primarily hepatic (glucuronidation, hydroxylation).
Side Effects
Contraindications
- •Hypersensitivity to ketorolac or other NSAIDs
- •Active peptic ulcer disease or gastrointestinal bleeding
- •Advanced renal impairment
- •Cerebrovascular bleeding
- •Pregnancy (especially late-term)
- •Breastfeeding
- •Children under 16 years
Drug Interactions
Lithium
Increased lithium levels and toxicity.
Methotrexate
Increased methotrexate toxicity.
Other NSAIDs/Aspirin
Increased risk of GI side effects.
ACE Inhibitors/Diuretics
Reduced antihypertensive effect and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include abdominal pain, nausea, vomiting, and drowsiness. Management involves symptomatic and supportive care, including gastric lavage or activated charcoal if recent ingestion.
Pregnancy & Lactation
Contraindicated in the third trimester of pregnancy due to risk of premature closure of fetal ductus arteriosus. Not recommended during breastfeeding as it is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Off-patent, generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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