Kfore
Generic Name
Cefixime
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| kfore 125 mg suspension | ৳ 198.00 | N/A |
Description
Overview of the medicine
Kfore 125 mg Suspension is an antibiotic medication containing Cefixime, a third-generation cephalosporin. It is used to treat a wide range of bacterial infections in children, including those of the ear, nose, throat, chest, urinary tract, and skin.
Uses & Indications
Dosage
Adults
Not typically used for adults in 125 mg suspension form; adult dosage for Cefixime is usually 200-400 mg daily.
Elderly
Not typically used for elderly in 125 mg suspension form; dosage adjustment may be needed based on renal function if higher doses are used.
Renal_impairment
For children with creatinine clearance 21-60 ml/min, 7.5 mg/kg daily; for creatinine clearance < 20 ml/min, 3.75 mg/kg daily. For adults, dose adjustment needed.
How to Take
Shake the bottle well before each use. Administer orally, with or without food. Complete the full course of treatment as prescribed by the doctor, even if symptoms improve.
Mechanism of Action
Cefixime works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, thereby interfering with the transpeptidation process that cross-links peptidoglycan strands, which are essential for bacterial cell wall integrity and rigidity. This leads to impaired cell wall formation, resulting in bacterial cell lysis and death.
Pharmacokinetics
Onset
Peak plasma concentrations are achieved 2-6 hours after administration.
Excretion
Approximately 50% of the absorbed dose is excreted unchanged in the urine over 24 hours. The remainder is excreted via non-renal mechanisms, primarily through bile and feces.
Half life
The plasma half-life is typically 3-4 hours.
Absorption
Approximately 40-50% of an oral dose is absorbed from the gastrointestinal tract. Food delays the time to peak concentration but does not significantly alter the extent of absorption.
Metabolism
Cefixime is not extensively metabolized in the body. No active metabolites have been identified.
Side Effects
Contraindications
- Known hypersensitivity to Cefixime or other cephalosporins.
- History of serious hypersensitivity reactions to penicillin.
Drug Interactions
Nifedipine
Concurrent use may increase Cefixime bioavailability.
Carbamazepine
Increased carbamazepine levels have been reported when administered concomitantly with Cefixime.
Warfarin and other anticoagulants
May increase prothrombin time (PT) with or without bleeding. Close monitoring of PT/INR is recommended.
Storage
Store dry powder at room temperature below 30°C, protected from light and moisture. Store reconstituted suspension in a refrigerator (2-8°C). Do not freeze.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis. Management should be supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Cefixime is excreted in small amounts in breast milk. Use with caution in pregnant or lactating women, only if clearly needed and under medical supervision.
Side Effects
Contraindications
- Known hypersensitivity to Cefixime or other cephalosporins.
- History of serious hypersensitivity reactions to penicillin.
Drug Interactions
Nifedipine
Concurrent use may increase Cefixime bioavailability.
Carbamazepine
Increased carbamazepine levels have been reported when administered concomitantly with Cefixime.
Warfarin and other anticoagulants
May increase prothrombin time (PT) with or without bleeding. Close monitoring of PT/INR is recommended.
Storage
Store dry powder at room temperature below 30°C, protected from light and moisture. Store reconstituted suspension in a refrigerator (2-8°C). Do not freeze.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis. Management should be supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Cefixime is excreted in small amounts in breast milk. Use with caution in pregnant or lactating women, only if clearly needed and under medical supervision.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Shelf life of dry powder is typically 2-3 years. Reconstituted suspension has a shelf life of 7-14 days when refrigerated.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of Cefixime for indicated bacterial infections in pediatric and adult populations.
Lab Monitoring
- Regular monitoring of renal function in patients with renal impairment.
- Periodic monitoring of PT/INR for patients on concomitant anticoagulant therapy.
Doctor Notes
- Advise parents/caregivers on proper reconstitution and administration of the suspension.
- Emphasize the importance of completing the full course to prevent resistance.
- Be aware of potential drug interactions, especially with anticoagulants.
Patient Guidelines
- Complete the entire prescribed course of medication, even if you feel better.
- Do not save leftover medication for future infections.
- Shake the suspension well before each use.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Cefixime generally does not impair the ability to drive or operate machinery. However, if side effects like dizziness occur, patients should avoid such activities.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Drink plenty of fluids unless advised otherwise by your doctor.
- Avoid sharing medication with others.
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