Medicine Information

Kilbac

Name: Kilbac
Brand: Kilbac

Injection250 mgAntibioticsATC: J01FF01

Generic Name

Clindamycin

Manufacturer

Popular Pharmaceuticals Ltd.

Country

Bangladesh

Loading images...

Price Details

Current market pricing information

Variant	Unit Price	Strip Price
kilbac 250 mg injection	৳ 55.00	N/A

Description

Overview of the medicine

Kilbac 250 mg Injection contains Clindamycin, a lincosamide antibiotic used to treat a wide variety of bacterial infections. It works by stopping the growth of bacteria. It is effective against certain anaerobic bacteria and some Gram-positive aerobic bacteria.

Uses & Indications

Serious infections caused by susceptible anaerobic bacteria (e.g., abdominal infections, pelvic infections, skin and soft tissue infections)

Upper and lower respiratory tract infections (e.g., pneumonia, lung abscess)

Septicemia

Bone and joint infections

Dental infections (as an alternative in penicillin-allergic patients)

Dosage

Adults

For serious infections: 600-1200 mg/day in 2-4 equally divided doses. For more severe infections: 1200-2700 mg/day in 2-4 equally divided doses. Administer IM or IV.

Elderly

Dosage adjustment not generally required based on age alone, but monitor renal and hepatic function.

Renal_impairment

No dosage adjustment needed for mild to moderate renal impairment. For severe impairment (CrCl <30 mL/min) or end-stage renal disease, consider dosage reduction or increased dosing interval.

How to Take

Kilbac 250 mg Injection is administered intramuscularly (IM) or intravenously (IV). For IV infusion, it must be diluted prior to administration and infused over at least 10-60 minutes depending on the dose. Do not administer IV bolus.

Mechanism of Action

Clindamycin binds to the 50S ribosomal subunit of susceptible bacteria, thereby inhibiting protein synthesis. It is primarily bacteriostatic but can be bactericidal at higher concentrations or against highly susceptible organisms.

Pharmacokinetics

Onset

Varies depending on infection type and severity; generally within hours for antibacterial effect.

Excretion

Excreted in urine (approx. 10%) and feces (approx. 4%) as active drug and metabolites.

Half life

Approximately 2-3 hours in adults with normal renal function.

Absorption

Rapidly absorbed after intramuscular administration. Peak serum concentrations are reached within 1-3 hours after IM injection.

Metabolism

Primarily metabolized in the liver to active and inactive metabolites (e.g., N-demethyl clindamycin and clindamycin sulfoxide).

Side Effects

Contraindications

Hypersensitivity to Clindamycin, Lincomycin, or any component of the formulation
History of antibiotic-associated colitis

Drug Interactions

Erythromycin

Antagonism may occur due to competition for the 50S ribosomal binding site.

Kaolin-pectin

May reduce the absorption of oral clindamycin (not relevant for injection, but good to note for the drug).

Neuromuscular blocking agents

May enhance the neuromuscular blocking action, leading to increased muscle weakness.

Storage

Store at controlled room temperature (20°C to 25°C), protect from freezing. Do not refrigerate diluted solutions.

Overdose

No specific antidote. Manage overdose with symptomatic and supportive care. Hemodialysis and peritoneal dialysis are not effective in removing clindamycin from the blood.

Pregnancy & Lactation

Pregnancy Category B. Use during pregnancy only if clearly needed. Clindamycin is excreted in breast milk; use with caution in nursing mothers.

Side Effects

Contraindications

Hypersensitivity to Clindamycin, Lincomycin, or any component of the formulation
History of antibiotic-associated colitis

Drug Interactions

Erythromycin

Antagonism may occur due to competition for the 50S ribosomal binding site.

Kaolin-pectin

May reduce the absorption of oral clindamycin (not relevant for injection, but good to note for the drug).

Neuromuscular blocking agents

May enhance the neuromuscular blocking action, leading to increased muscle weakness.

Storage

Store at controlled room temperature (20°C to 25°C), protect from freezing. Do not refrigerate diluted solutions.

Overdose

No specific antidote. Manage overdose with symptomatic and supportive care. Hemodialysis and peritoneal dialysis are not effective in removing clindamycin from the blood.

Pregnancy & Lactation

Pregnancy Category B. Use during pregnancy only if clearly needed. Clindamycin is excreted in breast milk; use with caution in nursing mothers.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 x 2 mL ampoule5 x 2 mL ampoules

Shelf Life

Typically 2-3 years when stored as recommended.

Availability

Pharmacies, Hospitals

Approval Status

Approved by regulatory bodies worldwide

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Clindamycin has been extensively studied in numerous clinical trials for its efficacy against various bacterial infections since its introduction.

Lab Monitoring

Regular monitoring of liver and kidney function (especially in prolonged therapy or in neonates/infants)
Blood counts
Monitoring for signs of C. difficile-associated diarrhea

Doctor Notes

Assess patient's history for colitis or severe diarrhea before initiating therapy.
Adjust dosage in severe hepatic impairment, although not typically required for renal impairment.
Administer IV slowly to avoid adverse cardiac effects and ensure proper dilution.

Patient Guidelines

Report any severe or persistent diarrhea to your doctor immediately.
Inform your doctor about all other medications you are taking.
Complete the full course of treatment as prescribed, even if you feel better.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.