Kilpro
Generic Name
Ketoprofen
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| kilpro 400 mg tablet | ৳ 1.50 | ৳ 15.00 |
Description
Overview of the medicine
Kilpro 400 mg Tablet contains Ketoprofen, a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, swelling, and stiffness from arthritis and other inflammatory conditions. It is also used to treat mild to moderate pain, menstrual cramps, and fever.
Uses & Indications
Dosage
Adults
Oral: 100-200 mg daily in 1 or 2 doses for long-term treatment. For acute conditions or severe pain, up to 400 mg daily in divided doses. The 400 mg tablet is usually for extended-release or specific conditions, often taken once daily or as directed.
Elderly
Lower doses may be required due to increased risk of side effects. Initial dose of 50-100 mg daily, adjusted as needed under medical supervision.
Renal_impairment
Reduced dosage is necessary. Initial dose of 50 mg daily, adjusted based on creatinine clearance. Avoid in severe renal impairment.
How to Take
Take with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water. Do not crush, chew, or break extended-release tablets.
Mechanism of Action
Ketoprofen works by inhibiting the production of prostaglandins, which are chemicals in the body that cause pain, fever, and inflammation. It achieves this by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes.
Pharmacokinetics
Onset
Within 30 minutes to 1 hour.
Excretion
Mainly via urine (up to 80% as metabolites), some fecal excretion.
Half life
Approximately 1.5-2.5 hours.
Absorption
Rapidly and well absorbed from the gastrointestinal tract, peak plasma concentrations occur within 1-2 hours.
Metabolism
Primarily hepatic, undergoing glucuronidation.
Side Effects
Contraindications
- Hypersensitivity to ketoprofen or other NSAIDs (e.g., aspirin)
- History of asthma, urticaria, or allergic reactions after taking aspirin or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe heart failure
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- Coronary artery bypass graft (CABG) surgery (peri-operative pain)
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
Diuretics/ACE Inhibitors
Reduced hypotensive effect and increased risk of renal impairment.
Other NSAIDs/Corticosteroids
Increased risk of gastrointestinal adverse effects.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Selective Serotonin Reuptake Inhibitors (SSRIs)
Increased risk of gastrointestinal bleeding.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, abdominal pain, lethargy, dizziness, headache, tinnitus, and potentially acute renal failure. Management is primarily supportive and symptomatic. Gastric lavage or activated charcoal may be considered if recent ingestion. Monitor vital signs and renal function.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters), Category D (third trimester) due to potential fetal harm. Avoid during the third trimester. Use with caution during lactation; consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to ketoprofen or other NSAIDs (e.g., aspirin)
- History of asthma, urticaria, or allergic reactions after taking aspirin or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe heart failure
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- Coronary artery bypass graft (CABG) surgery (peri-operative pain)
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
Diuretics/ACE Inhibitors
Reduced hypotensive effect and increased risk of renal impairment.
Other NSAIDs/Corticosteroids
Increased risk of gastrointestinal adverse effects.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Selective Serotonin Reuptake Inhibitors (SSRIs)
Increased risk of gastrointestinal bleeding.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, abdominal pain, lethargy, dizziness, headache, tinnitus, and potentially acute renal failure. Management is primarily supportive and symptomatic. Gastric lavage or activated charcoal may be considered if recent ingestion. Monitor vital signs and renal function.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters), Category D (third trimester) due to potential fetal harm. Avoid during the third trimester. Use with caution during lactation; consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of Ketoprofen for various inflammatory and pain conditions. Ongoing post-marketing surveillance continues.
Lab Monitoring
- Complete Blood Count (CBC) for anemia or bleeding
- Liver Function Tests (LFTs) for hepatic impairment
- Kidney Function Tests (KFTs) for renal impairment
- Blood pressure monitoring
Doctor Notes
- Consider gastroprotective agents (e.g., PPIs) when prescribing to patients with a history of GI issues or those at high risk.
- Educate patients on potential cardiovascular and GI risks, and the importance of taking the lowest effective dose for the shortest duration.
- Assess renal and hepatic function periodically, especially during prolonged therapy.
Patient Guidelines
- Take with food or milk to prevent stomach upset.
- Do not exceed the prescribed dose.
- Report any signs of stomach bleeding (e.g., black, tarry stools) to your doctor immediately.
- Avoid alcohol while taking this medicine.
- Do not take other NSAIDs or aspirin without consulting your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness. Avoid driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain a balanced diet and adequate hydration.
- Limit alcohol consumption.
- Engage in moderate exercise if appropriate for your condition.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Kilpro Brand
Other medicines available under the same brand name
