Klabid
Generic Name
Clarithromycin
Manufacturer
ACI Limited
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| klabid 250 mg tablet | ৳ 30.00 | ৳ 210.00 |
Description
Overview of the medicine
Klabid 250 mg tablet contains Clarithromycin, a macrolide antibiotic used to treat various bacterial infections of the respiratory tract, skin, and certain stomach ulcers caused by H. pylori.
Uses & Indications
Dosage
Adults
Typically 250 mg twice daily for 7-14 days. For more severe infections or H. pylori eradication, 500 mg twice daily may be prescribed.
Elderly
No specific dose adjustment generally needed based on age alone, but renal function should be assessed.
Renal_impairment
For creatinine clearance <30 mL/min, the dosage should be halved (e.g., 250 mg once daily) or the dosing interval doubled. Do not use in patients with severe renal impairment (CrCl <30 mL/min) who are also taking colchicine.
How to Take
Klabid tablets can be taken with or without food. For H. pylori eradication, it is usually recommended to take it with food to improve tolerability. Swallow the tablet whole; do not chew or crush.
Mechanism of Action
Clarithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby stopping bacterial growth.
Pharmacokinetics
Onset
Therapeutic plasma concentrations are typically achieved within 2-3 hours of administration.
Excretion
Primarily renal and hepatic excretion. Approximately 20-30% of unchanged drug and 10-15% of the active metabolite are excreted in urine.
Half life
About 3-7 hours for the 250 mg dose, increasing with higher doses due to saturable metabolism. The active metabolite, 14-hydroxyclarithromycin, has a half-life of 5-9 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; bioavailability is about 50-55%. Food may delay absorption but does not affect overall bioavailability significantly.
Metabolism
Extensively metabolized in the liver via CYP3A4 to an active metabolite (14-hydroxyclarithromycin) and inactive metabolites. First-pass metabolism is significant.
Side Effects
Contraindications
- •Known hypersensitivity to clarithromycin, erythromycin, or any other macrolide antibiotic.
- •Concomitant use with astemizole, cisapride, pimozide, terfenadine due to risk of QT prolongation and cardiac arrhythmias.
- •Concomitant use with ergotamine or dihydroergotamine due to risk of ergot toxicity (vasospasm and ischemia).
- •Concomitant use with HMG-CoA reductase inhibitors (statins) that are extensively metabolized by CYP3A4 (e.g., lovastatin, simvastatin) due to increased risk of myopathy, including rhabdomyolysis.
- •Concomitant use of colchicine in patients with renal or hepatic impairment.
- •Severe hepatic impairment in combination with renal impairment.
Drug Interactions
Digoxin
Increased serum digoxin concentrations. Monitor digoxin levels and adjust dosage.
Warfarin
Potentiation of anticoagulant effect, leading to increased bleeding risk. Monitor INR closely.
Colchicine
Increased exposure to colchicine, leading to toxicity, especially in patients with renal or hepatic impairment. Avoid concomitant use.
Statins (e.g., lovastatin, simvastatin)
Increased risk of myopathy, including rhabdomyolysis, due to inhibition of CYP3A4 metabolism. Use with caution or consider alternatives.
Oral Hypoglycemics (e.g., nateglinide, repaglinide) and Insulin
Possible increased hypoglycemic effect; monitor blood glucose.
CYP3A4 substrates (e.g., carbamazepine, ciclosporin, sildenafil, tacrolimus, theophylline)
Increased plasma concentrations of co-administered drugs. Close monitoring and dose adjustment may be necessary.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not freeze.
Overdose
Symptoms of overdose may include gastrointestinal upset such as abdominal pain, nausea, vomiting, and diarrhea. Management involves symptomatic and supportive care. Gastric lavage and supportive measures are recommended. Hemodialysis and peritoneal dialysis are not effective for removing clarithromycin.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Clarithromycin is excreted into human breast milk; caution should be exercised when administered to a nursing mother. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture when stored under recommended conditions.
Availability
Pharmacies and hospitals
Approval Status
Approved by health authorities
Patent Status
Off-patent
WHO Essential Medicine
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Global Brand Names
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