Take the tablet orally with a glass of water, preferably with food or milk to minimize gastrointestinal upset. Do not crush or chew the tablet.

Ketorolac Tromethamine inhibits prostaglandin synthesis by blocking cyclooxygenase (COX-1 and COX-2) enzymes. This reduction in prostaglandin levels leads to analgesic, anti-inflammatory, and antipyretic effects.

• •Known hypersensitivity to Ketorolac, aspirin, or other NSAIDs
• •Active peptic ulcer, recent gastrointestinal bleeding or perforation
• •Severe renal impairment
• •Advanced hepatic impairment
• •Coagulation disorders or patients at high risk of bleeding
• •Patients undergoing or who have recently undergone coronary artery bypass graft (CABG) surgery
• •Late pregnancy (third trimester) and labor

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Symptoms of overdose may include nausea, vomiting, epigastric pain, lethargy, drowsiness, and gastrointestinal bleeding. Rarely, hypertension, acute renal failure, respiratory depression, and coma may occur. Management is primarily symptomatic and supportive; there is no specific antidote. Gastric decontamination (e.g., activated charcoal) may be considered if ingestion is recent.

Pregnancy Category C (first and second trimesters), Category D (third trimester). Avoid in the third trimester due to potential adverse effects on the fetus and inhibition of uterine contractions. Use with caution during lactation; small amounts may be excreted in breast milk.