Kvit-B
Generic Name
Pyridoxine Hydrochloride (Vitamin B6)
Manufacturer
Generic Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| kvit b 50 mg injection | ৳ 10.00 | N/A |
Description
Overview of the medicine
Kvit-B 50 mg Injection contains Pyridoxine Hydrochloride, also known as Vitamin B6. It is used to prevent and treat vitamin B6 deficiency, which can occur due to inadequate dietary intake, certain medications, or underlying medical conditions. It plays a crucial role in metabolism, nerve function, and red blood cell formation.
Uses & Indications
Dosage
Adults
Pyridoxine deficiency: 10-20 mg IM/IV daily for 3 weeks, then 2-5 mg orally daily. Isoniazid-induced neuropathy: 50-100 mg IM/IV daily. Pyridoxine-dependent seizures: 50-100 mg IV.
Elderly
No specific dosage adjustment is generally required, but caution is advised in elderly patients with hepatic or renal impairment.
Renal_impairment
Use with caution in severe renal impairment. Dosage adjustment may be necessary in patients undergoing hemodialysis.
How to Take
Administer by intramuscular (IM) injection or by slow intravenous (IV) injection. For IV administration, it may be diluted in normal saline or 5% dextrose solution.
Mechanism of Action
Pyridoxine is converted to its active forms, pyridoxal phosphate (PLP) and pyridoxamine phosphate (PMP), which act as coenzymes in numerous metabolic pathways, including amino acid, carbohydrate, and lipid metabolism. It is essential for neurotransmitter synthesis, heme synthesis, and glycogenolysis.
Pharmacokinetics
Onset
Effects on deficiency symptoms may be observed within days to weeks depending on severity.
Excretion
Excreted mainly in the urine as 4-pyridoxic acid and other inactive metabolites.
Half life
The half-life of pyridoxal phosphate (PLP) in plasma is approximately 15-20 days.
Absorption
Readily absorbed from the gastrointestinal tract and rapidly converted to the active forms, pyridoxal phosphate (PLP) and pyridoxamine phosphate (PMP). Administered parenterally (injection) ensures direct systemic availability.
Metabolism
Primarily metabolized in the liver to pyridoxal phosphate (PLP), the active form, and other metabolites.
Side Effects
Contraindications
- •Hypersensitivity to pyridoxine or any component of the formulation
Drug Interactions
Levodopa (L-Dopa)
High doses of pyridoxine can decrease the effectiveness of levodopa by enhancing its peripheral metabolism. This interaction is usually only relevant with pure levodopa preparations, not carbidopa/levodopa combinations.
Phenobarbital, Phenytoin
Pyridoxine may decrease serum concentrations of phenobarbital and phenytoin.
Storage
Store below 30°C in a dry place, away from light. Do not freeze.
Overdose
High doses of pyridoxine over prolonged periods (e.g., >200 mg/day for several months) can lead to sensory neuropathy, characterized by numbness, tingling, and unsteadiness. Treatment involves discontinuing the drug. There is no specific antidote.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation at recommended doses, particularly for the treatment of nausea and vomiting in pregnancy. Consult a healthcare professional.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture
Availability
Available in pharmacies, hospitals, and clinics
Approval Status
Approved by health authorities
Patent Status
Generic (Patent expired)
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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