L-con
Generic Name
Levocetirizine
Manufacturer
A Local Pharmaceutical Company
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| l con 03 eye drop | ৳ 70.00 | N/A |
Description
Overview of the medicine
L-con (Levocetirizine) is an antihistamine used to relieve symptoms of seasonal and perennial allergic rhinitis and chronic idiopathic urticaria.
Uses & Indications
Dosage
Adults
5 mg (one tablet) once daily in the evening.
Elderly
Dosage adjustment may be required in elderly patients with impaired renal function. Consult a physician.
Renal_impairment
Dosage adjustment is necessary based on creatinine clearance. For CrCl 30-49 mL/min, 5 mg every 2 days; for CrCl 10-29 mL/min, 5 mg every 3 days.
How to Take
Administer orally, with or without food, preferably in the evening.
Mechanism of Action
Selectively blocks histamine H1-receptors, thereby inhibiting the effects of histamine and reducing allergic symptoms.
Pharmacokinetics
Onset
Within 15-30 minutes
Excretion
Primarily excreted via urine (approximately 85.4% of the dose) and feces (approximately 12.9% of the dose).
Half life
Approximately 7-10 hours
Absorption
Rapidly and extensively absorbed from the gastrointestinal tract. Peak plasma concentrations are reached within 1 hour.
Metabolism
Less than 14% of the dose is metabolized in the liver by oxidation. No significant cytochrome P450 isozymes are involved.
Side Effects
Contraindications
- Hypersensitivity to levocetirizine, cetirizine, hydroxyzine, or any component of the formulation
- Patients with end-stage renal disease (CrCl < 10 mL/min) or undergoing hemodialysis
- Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption
Drug Interactions
Ritonavir
May increase levocetirizine plasma levels.
CNS Depressants
Concomitant use with alcohol or other CNS depressants may cause additive reductions in alertness and performance.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness in adults and agitation or restlessness followed by drowsiness in children. Treatment is symptomatic and supportive; there is no specific antidote. Gastric lavage may be considered soon after ingestion.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown evidence of impaired fertility or harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Use during lactation should be done with caution, as levocetirizine is excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to levocetirizine, cetirizine, hydroxyzine, or any component of the formulation
- Patients with end-stage renal disease (CrCl < 10 mL/min) or undergoing hemodialysis
- Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption
Drug Interactions
Ritonavir
May increase levocetirizine plasma levels.
CNS Depressants
Concomitant use with alcohol or other CNS depressants may cause additive reductions in alertness and performance.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness in adults and agitation or restlessness followed by drowsiness in children. Treatment is symptomatic and supportive; there is no specific antidote. Gastric lavage may be considered soon after ingestion.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown evidence of impaired fertility or harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Use during lactation should be done with caution, as levocetirizine is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the manufacturing date, consult product packaging for exact details.
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Generic
Clinical Trials
Levocetirizine has undergone extensive clinical trials demonstrating its efficacy and safety in treating allergic rhinitis and chronic idiopathic urticaria across various patient populations.
Lab Monitoring
- No specific routine lab monitoring is required. Renal function may be monitored in patients with pre-existing renal impairment.
Doctor Notes
- Advise patients about potential drowsiness and to avoid driving or operating heavy machinery until they know how the drug affects them.
- Consider dosage adjustment for patients with renal impairment or elderly patients.
- Inform patients about common side effects such as dry mouth and headache.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid alcohol consumption while taking this medicine as it may increase drowsiness.
- May cause drowsiness or dizziness, use caution when driving or operating machinery.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Caution advised, as L-con may cause drowsiness or dizziness and impair your ability to drive or operate machinery. Avoid such activities until you know how the medicine affects you.
Lifestyle Advice
- Avoid known allergens to help manage symptoms and reduce the need for medication.
- Maintain good hydration.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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